Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.neuron.2007.02.007 (literal)

Alternative label

• Putignano E; Lonetti G; Cancedda L; Ratto GM; Costa M; Maffei L; Pizzorusso T (2007)
  Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity.
  in Neuron (Camb. Mass.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Putignano E; Lonetti G; Cancedda L; Ratto GM; Costa M; Maffei L; Pizzorusso T (literal)

Pagina inizio

• 747 (literal)

Pagina fine

• 759 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.cell.com/neuron/retrieve/pii/S0896627307001067 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 53 (literal)

Rivista

• Neuron (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 13 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Scuola Normale Superiore, Neurobiology Laboratory, Area Ricerca CNR, via Moruzzi, 1 Pisa 56125, Italy 2 Istituto Neuroscienze CNR, Area Ricerca CNR, via Moruzzi, 1 Pisa 56125, Italy 3 University of Florence, Department of Psychology, via S. Niccolò, 93 50125 Florence, Italy (literal)

Titolo

• Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. (literal)

Abstract

• The action of visual experience on visual cortical circuits is maximal during a critical period of postnatal development. The long-term effects of this experience are likely mediated by signaling cascades regulating experience-dependent gene transcription. Developmental modifications of these pathways could explain the difference in plasticity between the young and adult cortex. We studied the pathways linking experience-dependent activation of ERK to CREB-mediated gene expression in vivo. In juvenile mice, visual stimulation that activates CREB-mediated gene transcription also induced ERK-dependent MSK and histone H3 phosphorylation and H3-H4 acetylation, an epigenetic mechanism of gene transcription activation. In adult animals, ERK and MSK were still inducible; however, visual stimulation induced weak CREB-mediated gene expression and H3-H4 posttranslational modifications. Stimulation of histone acetylation in adult animals by means of trichostatin promoted ocular dominance plasticity. Thus, differing, experience-dependent activations of signaling molecules might be at the basis of the differences in experience-dependent plasticity between juvenile and adult cortex. (literal)

Prodotto di

• Tecniche innovative di imaging neuronale in vivo ed in vitro (ME.P06.011.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• MARIO COSTA (Unità di personale interno)
• GIAN MICHELE RATTO (Persona)
• LAMBERTO MAFFEI (Unità di personale esterno)
• Elena Putignano (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIO COSTA (Unità di personale interno)
• GIAN MICHELE RATTO (Persona)
• LAMBERTO MAFFEI (Unità di personale esterno)
• Elena Putignano (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Tecniche innovative di imaging neuronale in vivo ed in vitro (ME.P06.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuron (Rivista)

Insieme di parole chiave di

• Parole chiave di "Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity." (Insieme di parole chiave)