Subcortical ischaemic changes in young hypertensive patients: frequency, effect on cognitive performance and relationship with markers of endothelial and haemostatic activation. (Articolo in rivista)

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  • Subcortical ischaemic changes in young hypertensive patients: frequency, effect on cognitive performance and relationship with markers of endothelial and haemostatic activation. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1468-1331.2007.01930.x (literal)
Alternative label
  • Consoli D; Di Carlo A; Inzitari D; De Lucia D; Lamassa M; D'Avino M; Baldereschi M; Muto M; Mandarino A; Napolitano M; Romano MF; Caruso D. (2007)
    Subcortical ischaemic changes in young hypertensive patients: frequency, effect on cognitive performance and relationship with markers of endothelial and haemostatic activation.
    in European journal of neurology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Consoli D; Di Carlo A; Inzitari D; De Lucia D; Lamassa M; D'Avino M; Baldereschi M; Muto M; Mandarino A; Napolitano M; Romano MF; Caruso D. (literal)
Pagina inizio
  • 1222 (literal)
Pagina fine
  • 1229 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-1331/ (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 14 (literal)
Rivista
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  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 11 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Unit of Neurology Jazzolino Hospital, Vibo Valentia, Italy; Institute of Neurosciences, ILSA Study, Italian National Research Council, Florence, Italy; Department of Neurological and Psychiatric Sciences, University of Florence, Italy; General Hospital, Second University of Naples, Naples, Italy; Unit of Neurology, Cardarelli Hospital, Naples, Italy; Unit of Neuroradiology, Cardarelli Hospital, Naples, Italy; and Unit of Hypertension, Cardarelli Hospital, Naples, Italy. (literal)
Titolo
  • Subcortical ischaemic changes in young hypertensive patients: frequency, effect on cognitive performance and relationship with markers of endothelial and haemostatic activation. (literal)
Abstract
  • Information on subcortical ischaemic changes (SIC) in young hypertensive patients is scarce. We evaluated the frequency of SIC at magnetic resonance imaging (MRI), the possible effect on cognition of these patients, and the role of plasma markers known as indicators of endothelial and haemostatic activation. Inclusion criteria were age <= 54 years, hypertension for at least 2 years and absence of cerebrovascular disease or other conditions possibly related to SIC. Patients with SIC at MRI and two control groups (matched for age, sex and education) of hypertensive patients without SIC and non-hypertensive healthy subjects underwent an extensive ne neuropsychological examination and evaluation of plasma markers. Amongst the 200 patients evaluated, 50(25%) showed SIC at MRI. Mean age was 48.4 +/- 4.8 years. Compared with both control Groups, hypertensive patients with SIC performed significantly worse in general cognition, attention, memory and executive functions. Moreover, they showed significantly more often increased levels of all plasma markers compared with healthy controls, and of von Willebrand factor (vWF) compared with both control groups (P < 0.001). In young hypertensive patients SIC are frequent, related to a worse cognitive performance and endothelial dysfunction. Our findings suggest vWF as marker of end-organ damage, underscoring the relevance of treating hypertension at younger age. (literal)
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