http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38053
Formalin hindpaw injection induces changes in the [(3)H]prazosin binding to alpha(1)-adrenoceptors in specific regions of the mouse brain and spinal cord. (Articolo in rivista)
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- Label
- Formalin hindpaw injection induces changes in the [(3)H]prazosin binding to alpha(1)-adrenoceptors in specific regions of the mouse brain and spinal cord. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
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- Nalepa I; Vetulani J; Borghi V; Kowalska M; Przewlocka B; Pavone F (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Biochemistry and Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
C.N.R., Institute of Neuroscience, Psychobiology and Psychopharmacology, Roma, Italy (literal)
- Titolo
- Formalin hindpaw injection induces changes in the [(3)H]prazosin binding to alpha(1)-adrenoceptors in specific regions of the mouse brain and spinal cord. (literal)
- Abstract
- Involvement of the alpha1-adrenoceptor subtypes in early and late phases of formalin pain was investigated by quantitative in vitro autoradiography in the spinal cord and brain structures of CD-1 mice. Total alpha1-adrenoceptors binding (including all alpha1-adrenoceptor subtypes) was assessed with [3H]prazosin; alpha(1B)-adrenoceptor was assessed with [3H]prazosin in the presence of 10 nM WB4101 to mask remaining alpha1-adrenoceptor subtypes. Early after formalin injection the alpha1-adrenoceptors (mainly alpha1B receptor) binding was reduced in the contralateral hind limb area of the somatosensory cortex and in the secondary motor cortex. A reduction occurred also in the ipsilateral laminae I-III of the spinal cord (both alpha1B- and non-alpha1B-adrenoceptors). Lately an increase of alpha1-adrenoceptors binding (mostly subtypes other than alpha1B) appeared in discrete amygdaloid and thalamic nuclei. These results provide the first description of changes at the level of central alpha1-adrenoceptors' binding during the formalin-induced pain in mice. Their distribution suggests that they may have a functional meaning. (literal)
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