Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.expneurol.2004.05.025 (literal)

Alternative label

• Laura Ricceri, Luisa Minghetti, Anna Moles, Patrizia Popoli, Annamaria Confaloni, Roberta De Simone, Paola Piscopo, Maria Luisa Scattoni, Monica di Luca, Gemma Calamandrei (2004)
  Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats
  in Experimental neurology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Laura Ricceri, Luisa Minghetti, Anna Moles, Patrizia Popoli, Annamaria Confaloni, Roberta De Simone, Paola Piscopo, Maria Luisa Scattoni, Monica di Luca, Gemma Calamandrei (literal)

Pagina inizio

• 162 (literal)

Pagina fine

• 172 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 189 (literal)

Rivista

• Experimental neurology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Ist Super Sanita, Dept Cell Biol & Neurosci, Sect Behav Neurosci, I-00161 Rome, Italy 2. Ist Super Sanita, Dept Cell Biol & Neurosci, Sect Degenerat Inflammatory Neurol Dis, I-00161 Rome, Italy 3. CNR, Inst Neurosci, Lab Psicobiol & Psicofarmacol, I-00137 Rome, Italy 4. Ist Super Sanita, Dept Drug Res & Safety, Sect CNS Pharmacol, I-00161 Rome, Italy 5. Univ Milan, Dept Pharmacol Sci, I-20133 Milan, Italy (literal)

Titolo

• Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats (literal)

Abstract

• In the present study we examined the long-term effects of neonatal lesion of basal forebrain cholinergic neurons induced by intracerebroventricular injections of the immunotoxin 192 IgG saporin. Animals were then characterised behaviourally, electrophysiologically and molecularly. Cognitive effects were evaluated in the social transmission of food preferences, a non-spatial associative memory task. Electrophysiological effects were assessed by recording of cortical electroencephalographic (EEG) patterns. In addition, we measured the levels of proteins whose abnormal expression has been associated with neurodegeneration such as amyloid precursor protein (APP), presenilin 1 and 2 (PS-1, PS-2), and cyclooxygenases (COX-1 and COX-2). In animals lesioned on postnatal day 7 and tested 6 months thereafter, memory impairment in the social transmission of food preferences was evident, as well as a significant reduction of choline acetyltransferase activity in hippocampus and neocortex. Furthermore, similar to what observed in Alzheimer-like dementia, EEG cortical patterns in lesioned rats presented changes in alpha, beta and delta activities. Levels of APP protein and mRNA were not affected by the treatment. Levels of hippocampal COX-2 protein and mRNA were significantly decreased whereas COX-1 remained unaltered. PS-1 and PS-2 transcripts were reduced in hippocampus and neocortex. (literal)

Prodotto di

• Modelli animali per lo studio del sistema nervoso (ME.P05.007.001) (Modulo)
• Institute of neuroscience (IN) (Istituto)

Autore CNR

• ANNA MOLES (Unità di personale interno)

Incoming links:

Autore CNR di

• ANNA MOLES (Unità di personale interno)

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Modelli animali per lo studio del sistema nervoso (ME.P05.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Experimental neurology (Rivista)