http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37983
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome. (Articolo in rivista)
- Type
- Label
- Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Alternative label
Restivo L, Ferrari F, Passino E, Sgobio C, Bock J, Oostra BA, Bagni C, Ammassari-Teule (2005)
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.
in Proceedings of the National Academy of Sciences of the United States of America
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Restivo L, Ferrari F, Passino E, Sgobio C, Bock J, Oostra BA, Bagni C, Ammassari-Teule (literal)
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- Rivista
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome. (literal)
- Abstract
- Fragile X syndrome, the most frequent form of hereditary mental
retardation, is due to a mutation of the fragile X mental retardation
1 (FMR1) gene on the X chromosome. Like fragile X patients,
FMR1-knockout (FMR1-KO) mice lack the normal fragile X mental
retardation protein (FMRP) and show both cognitive alterations
and an immature neuronal morphology. We reared FMR1-KO mice
in a C57BL?6 background in enriched environmental conditions to
examine the possibility that experience-dependent stimulation
alleviates their behavioral and neuronal abnormalities. FMR1-KO
mice kept in standard cages were hyperactive, displayed an altered
pattern of open field exploration, and did not show habituation.
Quantitative morphological analyses revealed a reduction in basal
dendrite length and branching together with more immatureappearing
spines along apical dendrites of layer five pyramidal
neurons in the visual cortex. Enrichment largely rescued these
behavioral and neuronal abnormalities while increasing ?-amino-
3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate
receptor subunit 1 (GluR1) levels in both genotypes. Enrichment
did not, however, affect FMRP levels in the WT mice. These data
suggest that FMRP-independent pathways activating glutamatergic
signaling are preserved in FMR1-KO mice and that they can be
elicited by environmental stimulation. (literal)
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