Anti-allodynic efficacy of Botulinum neurotoxin A in a model of neurophatic pain (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Anti-allodynic efficacy of Botulinum neurotoxin A in a model of neurophatic pain (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Luvisetto S.; Marinelli S.; Cobianchi S.; Pavone F. (2007)
  Anti-allodynic efficacy of Botulinum neurotoxin A in a model of neurophatic pain
  in Neuroscience
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Luvisetto S.; Marinelli S.; Cobianchi S.; Pavone F. (literal)

Pagina inizio

• 1 (literal)

Pagina fine

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 145 (literal)

Rivista

• Neuroscience (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR Institute of Neuroscience, Psychobiology and Psychopharmacology, Via del Fosso di Fiorano 64, I-00143 Roma, Italy. (literal)

Titolo

• Anti-allodynic efficacy of Botulinum neurotoxin A in a model of neurophatic pain (literal)

Abstract

• Neuropathic pain is typified by injuries to the peripheral and central nervous system and derives from such causes as cancer, diabetes, multiple sclerosis, post-herpetic neuralgia, physical trauma or surgery, and many others. Patients suffering neuropathic pain do not respond to conventional treatment with non-steroidal anti-inflammatory drugs and show a reduced sensitivity to opiates often associated with serious side effects. Recently, it has been demonstrated that botulinum neurotoxin serotype-A (BoNT/A) is able to induce analgesia in inflammatory pain conditions. The goal of this research was to test if BoNT/A was able to relieve also neuropathic pain symptoms. By using chronic constriction injury of the sciatic nerve, a mouse model of neuropathic pain, we observed that peripheral administration of BoNT/A strongly reduced the mechanical allodynia associated with this neuropathy. Remarkably, a single non-toxic dose of BoNT/A was sufficient to induce anti-allodynic effects, which lasted for at least 3 weeks. This result is particularly relevant since neuropathic pain is poorly treated by current drug therapies. This communication enlarges our knowledge on potentially new medical uses of BoNT/A in efforts to ameliorate human health conditions, with very important implications in the development of new pharmacotherapeutic approaches against neuropathic pain. (literal)

Prodotto di

• Modelli animali per lo studio del sistema nervoso (ME.P05.007.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• FLAMINIA PAVONE (Unità di personale interno)
• SARA MARINELLI (Unità di personale esterno)
• SIRO LUVISETTO (Persona)

Incoming links:

Autore CNR di

• FLAMINIA PAVONE (Unità di personale interno)
• SIRO LUVISETTO (Persona)
• SARA MARINELLI (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Modelli animali per lo studio del sistema nervoso (ME.P05.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience (Rivista)