Acceleration of visual system development by environmental enrichment (Articolo in rivista)

Type
Label
  • Acceleration of visual system development by environmental enrichment (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1523/JNEUROSCI.0845-04.2004 (literal)
Alternative label
  • Cancedda L, Putignano E, Sale A, Viegi A, Berardi N, Maffei L (2004)
    Acceleration of visual system development by environmental enrichment
    in The Journal of neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cancedda L, Putignano E, Sale A, Viegi A, Berardi N, Maffei L (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.jneurosci.org/content/24/20/4840 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Neuroscience CNR, via Moruzzi 1, 56100 Pisa (literal)
Titolo
  • Acceleration of visual system development by environmental enrichment (literal)
Abstract
  • Thus far, the developmental plasticity of the visual system has been studied by altering or reducing visual experience. Here, we investigated whether a complex sensory-motor stimulation, provided by rearing animals in an enriched environment, affects visual system development. We found that raising mice in this condition causes an earlier eye opening, a precocious development of visual acuity, and an accelerated decline of white matter-induced long-term potentiation. These effects are accompanied by a precocious cAMP response element-mediated gene expression and a significant increase ofBDNFprotein and GAD65/67 expression in enriched pups. In addition,we showed that enriched pups experienced higher levels of licking behavior provided by adult females. Thus, rearing mice from birth in an enriched environment leads to a conspicuous acceleration of visual system development as ascertained at behavioral, electrophysiological, and molecular level. (literal)
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Autore CNR

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