http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37928

Anterograde transport of neurotrophic factors: possible therapeutic implications. (Articolo in rivista)

Type

Label

Anterograde transport of neurotrophic factors: possible therapeutic implications. (Articolo in rivista) (literal)

Anno

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Alternative label

Caleo M, Cenni MC. (2004)
Anterograde transport of neurotrophic factors: possible therapeutic implications.
in Molecular neurobiology
(literal)

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Rivista

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Note

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CNR, Ist Neurosci, I-56100 Pisa, Italy Scuola Normale Super Pisa, I-56100 Pisa, Italy (literal)

Titolo

Anterograde transport of neurotrophic factors: possible therapeutic implications. (literal)

Abstract

The actions of neurotrophic factors are classically thought to be mediated by their retrograde transport from target tissues to the cell bodies. There is now evidence that specific trophic factors are trafficked anterogradely along peripheral and central axons and released to postsynaptic cells. This review focuses on recent experiments that demonstrate the involvement of the anterograde transfer of neurotrophic factors in various physiological processes, including the regulation of developmental neuronal death, the modulation of synaptic transmission, and the control of axonal and dendritic architecture. The authors also discuss whether anterograde transport of exogenous trophic factors can be exploited to protect damaged postsynaptic neurons and spare their function. This issue has clear implications for possible therapeutic applications of neurotrophic factors. (literal)

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