A role for retinal brain-derived neurotrophic factor in ocular dominance plasticity. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A role for retinal brain-derived neurotrophic factor in ocular dominance plasticity. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Mandolesi G, Menna E, Harauzov A, von Bartheld CS, Caleo M, Maffei L (2005)
  A role for retinal brain-derived neurotrophic factor in ocular dominance plasticity.
  in Current biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mandolesi G, Menna E, Harauzov A, von Bartheld CS, Caleo M, Maffei L (literal)

Pagina inizio

• 2119 (literal)

Pagina fine

• 2124 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Current biology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Scuola Normale Super Pisa, I-56100 Pisa, Italy 2. CNR, Inst Neurosci, I-56100 Pisa, Italy 3. Santa Lucia Fdn, I-00164 Rome, Italy 4. Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA (literal)

Titolo

• A role for retinal brain-derived neurotrophic factor in ocular dominance plasticity. (literal)

Abstract

• Visual deprivation is a classical tool to study the plasticity of visual cortical connections. After eyelid closure in young animals (monocular deprivation, MD), visual cortical neurons become dominated by the open eye, a phenomenon known as ocular dominance (OD) plasticity [1]. It is commonly held that the molecular mediators of OD plasticity are cortically derived and that the retina is immune to the effects of MID [24]. Recently, it has been reported that visual deprivation induces neurochemical, structural, and functional changes in the retina [5-7], but whether these retinal changes contribute to the effects of MID in the cortex is unknown. Here, we provide evidence that brain-derived neurotrophic factor (BDNF) produced in the retina influences OD plasticity. We found a reduction of BDNF expression in the deprived retina of young rats. We compensated this BDNF imbalance between the two eyes by either injecting exogenous BDNF in the deprived eye or reducing endogenous BDNF expression in the nondeprived eye. Both treatments were effective in counteracting the OD shift induced by MD. Retinal BDNF could also influence OD distribution in normal animals. These results show for the first time that OD plasticity is modulated by BDNF produced in the retina. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neuropatologie: dall'approccio molecolare alla epidemiologia delle demenze (ME.P02.019.001) (Modulo)

Autore CNR

• MATTEO CALEO (Unità di personale interno)
• ELISABETTA MENNA (Unità di personale interno)
• LAMBERTO MAFFEI (Unità di personale esterno)

Incoming links:

Autore CNR di

• MATTEO CALEO (Unità di personale interno)
• LAMBERTO MAFFEI (Unità di personale esterno)
• ELISABETTA MENNA (Unità di personale interno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neuropatologie: dall'approccio molecolare alla epidemiologia delle demenze (ME.P02.019.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current biology (Rivista)