Changes in expression of the ƒdelta subunit of the GABAA receptor and in receptor function induced by progesterone exposure and whitdrawal. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Changes in expression of the ƒdelta subunit of the GABAA receptor and in receptor function induced by progesterone exposure and whitdrawal. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1471-4159.2006.04055.x (literal)

Alternative label

• Mostallino M.C.; Mura M.L.; Maciocco E.; Murru L.; Sanna E.; Biggio G. (2006)
  Changes in expression of the ƒdelta subunit of the GABAA receptor and in receptor function induced by progesterone exposure and whitdrawal.
  in Journal of neurochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mostallino M.C.; Mura M.L.; Maciocco E.; Murru L.; Sanna E.; Biggio G. (literal)

Pagina inizio

• 321 (literal)

Pagina fine

• 332 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://onlinelibrary.wiley.com (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 99 (literal)

Rivista

• Journal of neurochemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Research National Council (CNR), Institute for Neuroscience, Cagliari, Italy ?Department of Experimental Biology, Section of Neuroscience, and ?Center of Excellence for the Neurobiology of Addiction, University of Cagliari, Cagliari, Italy (literal)

Titolo

• Changes in expression of the ƒdelta subunit of the GABAA receptor and in receptor function induced by progesterone exposure and whitdrawal. (literal)

Abstract

• Type A receptors for GABA (GABAA receptors) that contain the ? subunit are located predominantly at extrasynaptic sites and are implicated in modulation of neuronal excitability through tonic inhibition. We have examined the effects of chronic exposure to and subsequent withdrawal of progesterone or the progesterone metabolite 3?-hydroxy-5?-pregnan-20-one (3?,5?-THPROG) on expression of the ? subunit of GABAA receptors and on receptor function in cultured rat hippocampal neurons. Progesterone treatment for 1 day increased the amounts of both ? subunit mRNA and protein, whereas such treatment for 6 days induced marked decreases in the abundance of both the mRNA and protein. Subsequent progesterone withdrawal up-regulated expression of the ? subunit, which was significantly increased at 9-12 h after withdrawal. These effects of progesterone were mimicked by 3?,5?-THPROG and blocked by the 5?-reductase inhibitor finasteride. They were also accompanied by parallel changes in the function of GABAA receptors in hippocampal neurons. These results show that chronic exposure to and withdrawal of progesterone induce differential effects on both expression of the ? subunit of GABAA receptors and receptor function that are mediated by 3?,5?-THPROG. They are consistent with the notion that this progesterone metabolite plays a key physiological role in modulation of GABAergic synapses. (literal)

Prodotto di

• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• MARIA CRISTINA MOSTALLINO (Persona)
• ELISABETTA MACIOCCO (Unità di personale interno)
• GIOVANNI BIGGIO (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Changes in expression of the ƒdelta subunit of the GABAA receptor and in receptor function induced by progesterone exposure and whitdrawal." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA CRISTINA MOSTALLINO (Persona)
• ELISABETTA MACIOCCO (Unità di personale interno)
• GIOVANNI BIGGIO (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neurochemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Changes in expression of the ƒdelta subunit of the GABAA receptor and in receptor function induced by progesterone exposure and whitdrawal." (Insieme di parole chiave)