Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00213-006-0327-1 (literal)

Alternative label

• Gessa G.L., Orrù A., Lai P., Maccioni P., Lecca R., Lobina C., Carai M.A.M., Colombo G (2006)
  Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats.
  in Psychopharmacology (Berl).
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gessa G.L., Orrù A., Lai P., Maccioni P., Lecca R., Lobina C., Carai M.A.M., Colombo G (literal)

Pagina inizio

• 248 (literal)

Pagina fine

• 254 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 185 (literal)

Rivista

• Psychopharmacology (Berl). (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• C.N.R. Institute of Neuroscience, Cagliari, Italy; Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy (literal)

Titolo

• Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats. (literal)

Abstract

• Rationale and Objectives: Previous work indicated that tolerance to the anorectic effect of the cannabinoid CB1 receptor antagonist/inverse agonist, rimonabant, developed rather rapidly in rats and mice given access to a standard rodent chow. The present study was designed to investigate whether the reducing effect of rimonabant on intake of a highly palatable food such as a chocolate-flavoured beverage underwent a development of tolerance as rapid as that manifested on intake of a standard rodent chow. Methods: To this aim, Wistar rats were concurrently exposed, with unlimited access for 24 hours/day, to the chocolate-flavoured beverage, regular food pellets and water. Rimonabant (0, 1.25, 2.5 and 5 mg/kg; i.p.) was administered once a day for 21 consecutive days. Results: Rimonabant administration resulted in a dose-dependent suppression of the high, daily intake of the chocolate-flavoured beverage; this effect lasted for the entire 21-day treatment period, without any apparent development of tolerance. Conversely, rimonabant-induced reduction in daily intake of regular food pellets was of smaller magnitude and limited to the first 3-4 days of treatment. Conclusions: Together, these results indicate that chronically administered rimonabant was more effective and longer-lasting in reducing the intake of a highly palatable food than that of regular food pellets in rats. These results also suggest that rimonabant may be more active on the hedonic rather than nutritive properties of diets. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Autore CNR

• CARLA LOBINA (Unità di personale esterno)
• GIAN LUIGI GESSA (Unità di personale esterno)
• GIANCARLO COLOMBO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• GIAN LUIGI GESSA (Unità di personale esterno)
• CARLA LOBINA (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Psychopharmacology (Berl). (Rivista)

Insieme di parole chiave di

• Parole chiave di "Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats." (Insieme di parole chiave)