http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37877

Morphine-conditioned single-trial place-preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Morphine-conditioned single-trial place-preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression (Articolo in rivista) (literal)

Anno

2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00213-006-0415-2 (literal)

Alternative label

Fenu S., Spina L., Rivas E., Longoni R., Di Chiara G (2006)
Morphine-conditioned single-trial place-preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression
in Psychopharmacology (Sheff.); Springer Verlag, New York NY (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Fenu S., Spina L., Rivas E., Longoni R., Di Chiara G (literal)

Pagina inizio

143 (literal)

Pagina fine

153 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

187 (literal)

Rivista

Psychopharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

Google Scholar (literal)
ISI Web of Science (WOS) (literal)
PubMed (literal)
Scopus (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Fenu S. Dept. of Toxicology, University of Cagliari, Cagliari, Italy; Centre of Excellence for Studies on Neurobiology of Addiction, University of Cagliari, Cagliari, Italy. Spina L. Dept. of Toxicology, University of Cagliari, Cagliari, Italy. Rivas E. Dept. of Toxicology, University of Cagliari, Cagliari, Italy. Longoni R. Dept. of Toxicology, University of Cagliari, Cagliari, Italy. Di Chiara G. Dept. of Toxicology, University of Cagliari, Cagliari, Italy; Centre of Excellence for Studies on Neurobiology of Addiction, University of Cagliari, Cagliari, Italy; Institute of Neuroscience, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy. (literal)

Titolo

Morphine-conditioned single-trial place-preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression (literal)

Abstract

Rationale: A large body of evidence indicates an involvement of the mesolimbic dopamine (DA) pathway innervating the ventral striatum in the motivational effects of drug abuse. Objective: The goal of the study is to clarify the role of DA D-1 and D-2 receptors of the rat nucleus accumbens (NAc) shell and core in the motivational effects of morphine as studied by conditioned place preference (CPP). Methods: The effect of the intracerebral infusion of DA antagonists specific for DA D-1 (SCH 39166) and D-2 receptors (L-sulpiride) was studied in a single-trial place conditioning paradigm with fixed assignment of the drug to the unpreferred compartment. Results: Morphine induced significant CPP at all the doses tested (0.5, 1.0, and 2.0 mg/kg, subcutaneously). A dose of 1.0 mg/kg was selected for further studies. Intra-NAc shell infusion of SCH 39166 and L-sulpiride at doses of 25 and 50 ng/1 mu l per side impaired the acquisition of CPP by morphine. No effect was observed at 12.5 ng/1 mu l per side. Intra-NAc core infusion of SCH 39166 (12.5, 25, and 50 ng/1 mu l per side) did not affect the acquisition of morphine-induced CPP, while L-sulpiride (12.5, 25, and 50 ng/1 mu l per side) impaired CPP acquisition only at the dose of 50 ng/1 mu l per side. No effect on morphine-induced CPP was observed when the DA antagonists were infused into the NAc shell or core 10 min before the test session. Conclusion: These results indicate that DA D-1 and D-2 receptors in the NAc shell are involved in the acquisition of morphine-induced CPP. (literal)

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