http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37862
Internalization and mechanisms of action of clostridial toxins in neurons. (Articolo in rivista)
- Type
- Label
- Internalization and mechanisms of action of clostridial toxins in neurons. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Alternative label
Grumelli C, Verderio C, Pozzi D, Rossetto O, Montecucco C, Matteoli M (2005)
Internalization and mechanisms of action of clostridial toxins in neurons.
in Neurotoxicology (Park Forest South)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Grumelli C, Verderio C, Pozzi D, Rossetto O, Montecucco C, Matteoli M (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1. Univ Milan, Ctr Excellence Neurodegenerat Dis, Dept Med Pharmacol, I-20129 Milan, Italy
2. Univ Milan, Ctr Excellence Neurodegenerat Dis, CNR, Inst Neurosci, I-20129 Milan, Italy
3. Univ Padua, Dip Sci Biomed Sperimentali, I-35100 Padua, Italy (literal)
- Titolo
- Internalization and mechanisms of action of clostridial toxins in neurons. (literal)
- Abstract
- Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransinitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinuin toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals. (literal)
- Prodotto di
- Autore CNR
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