Entering neurons: botulinum toxins and synaptic vesicle recycling. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Entering neurons: botulinum toxins and synaptic vesicle recycling. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Verderio C, Rossetto O, Grumelli C, Frassoni C, Montecucco C and Matteoli M (2006)
  Entering neurons: botulinum toxins and synaptic vesicle recycling.
  in EMBO journal (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Verderio C, Rossetto O, Grumelli C, Frassoni C, Montecucco C and Matteoli M (literal)

Pagina inizio

• 995 (literal)

Pagina fine

• 999 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• EMBO journal (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Univ Padua, Dipartimento Sci Biomed Sperimentali, I-35121 Padua, Italy 2. Univ Milan, CNR Inst, Ctr Excellence Neurodegenerat Dis, I-20129 Milan, Italy 3. Univ Milan, Dept Pharmacol, I-20129 Milan, Italy 4. Ist Neurol Carlo Besta, Milan, Italy (literal)

Titolo

• Entering neurons: botulinum toxins and synaptic vesicle recycling. (literal)

Abstract

• Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release through their cleavage of components of the exocytosis machinery. These toxins are used to treat human diseases that are characterized by hyperfunction of cholinergic terminals. Recently, evidence has accumulated that gangliosides and synaptic vesicle proteins cooperate to mediate toxin binding to the presynaptic terminal. The differential distribution of synaptic vesicle protein receptors, gangliosides and toxin substrates in distinct neuronal populations opens up the possibility of using different serotypes of botulinum toxins for the treatment of central nervous system diseases caused by altered activity of selected neuronal populations. (literal)

Prodotto di

• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• MICHELA MATTEOLI (Persona)
• CLAUDIA VERDERIO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Autore CNR di

• CLAUDIA VERDERIO (Unità di personale interno)
• MICHELA MATTEOLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO journal (Rivista)