GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.brainresprot.2005.02.002 (literal)

Alternative label

• Lobina C., Colombo G., Orrù A., Maccioni P., Gessa G.L., Carai M.A.M. (2005)
  GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats.
  in Brain research protocols
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lobina C., Colombo G., Orrù A., Maccioni P., Gessa G.L., Carai M.A.M. (literal)

Pagina inizio

• 1 (literal)

Pagina fine

• 5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Brain research protocols (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• \"Bernard B. Brodie\" Department of Neuroscience, University of Cagliari, Cagliari, Italy; C.N.R. Institute of Neuroscience, Section of Cagliari, Cagliari, Italy. (literal)

Titolo

• GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats. (literal)

Abstract

• Gamma-hydroxybutyric acid (GHB)-sensitive (GHB-S) and GHB-resistant (GHB-R) rats have been selectively bred for their opposite sensitivity to the sedative/hypnotic effect of GHB. This opposite sensitivity has been found to generalize to the GABAB receptor agonist, baclofen. A control line [named GHB-control (GHB-C)] has been derived from the foundation stock of GHB-S and GHB-R rats. GHB-C rats have been bred without any evaluation of their sensitivity to GHB. The experiments described here were designed to evaluate the sensitivity of GHB-C rats, from the 13th generation, to the sedative/hypnotic effect of GHB (1 g/kg, i.p.) and baclofen (20 mg/kg, i.p.). All measures (onset, sleep time and r=sleep time/onset) of sensitivity to GHB- and baclofen-induced sedation/hypnosis in GHB-C rats were significantly different from and intermediate to those recorded in GHB-S and GHB-R rats. Further, these values were similar to those recorded in the foundation stock. These results suggest that GHB-C rats may constitute a valid control line for GHB-S and GHB-R rats, representing the \"general population\" from which GHB-S and GHB-R rats were derived. Further, the relative equidistance of sensitivity to GHB- and baclofen-induced sedation/hypnosis of GHB-C rats from those of GHB-S and GHB-R rats suggests that genetic factors contributes to the development of both sensitivity in GHB-S rats and resistance in GHB-R rats. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Autore CNR

• GIAN LUIGI GESSA (Unità di personale esterno)
• GIANCARLO COLOMBO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• GIAN LUIGI GESSA (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Brain research protocols (Rivista)

Insieme di parole chiave di

• Keywords of "GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats." (Insieme di parole chiave)