Effect of the combination of naltrexone and baclofen on acquisition of alcohol drinking behavior in alcohol-preferring rats (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Effect of the combination of naltrexone and baclofen on acquisition of alcohol drinking behavior in alcohol-preferring rats (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.drugalcdep.2004.07.003 (literal)

Alternative label

• Colombo G., Serra S., Vacca G., Carai M.A.M., Gessa G.L. (2005)
  Effect of the combination of naltrexone and baclofen on acquisition of alcohol drinking behavior in alcohol-preferring rats
  in Drug and Alcohol Dependence
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Colombo G., Serra S., Vacca G., Carai M.A.M., Gessa G.L. (literal)

Pagina inizio

• 87 (literal)

Pagina fine

• 91 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 77 (literal)

Rivista

• Drug and Alcohol Dependence (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• C.N.R. Institute of Neuroscience, Section of Cagliari, Italy; \"Bernard B. Brodie\" Department of Neuroscience, University of Cagliari, Italy (literal)

Titolo

• Effect of the combination of naltrexone and baclofen on acquisition of alcohol drinking behavior in alcohol-preferring rats (literal)

Abstract

• Recent surveys suggest that positive outcomes in the pharmacotherapy of alcoholism may be obtained through drug combinations. The present study evaluated the effect of the combination of the opioid receptor antagonist, naltrexone, with the GABAB receptor agonist, baclofen, on the acquisition of alcohol drinking behavior in Sardinian alcohol-preferring (sP) rats. Rats were treated with either saline, 0.5 mg/kg naltrexone, 1 mg/kg baclofen, or 0.5 mg/kg naltrexone plus 1 mg/kg baclofen once a day for 10 days. Alcohol was offered immediately after the first drug injection under the 2-bottle regimen. Alcohol intake in saline-treated rats rose to 5-6 g/kg/day within a few days, indicative of a rapid acquisition of alcohol drinking behavior. Neither naltrexone nor baclofen, when given alone, affected alcohol drinking behavior. In contrast, the drug combination resulted in a significant reduction in daily alcohol intake and retardation in the acquisition of alcohol drinking behavior. These results suggest that combination of naltrexone plus baclofen may result in a synergistic reduction in alcohol intake in sP rats. These results are discussed in terms of naltrexone and baclofen exerting a concomitant and reciprocally potentiating inhibitory action on alcohol-induced activation of mesolimbic dopamine transmission. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Autore CNR

• GIAN LUIGI GESSA (Unità di personale esterno)
• GIANCARLO COLOMBO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Effect of the combination of naltrexone and baclofen on acquisition of alcohol drinking behavior in alcohol-preferring rats" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• GIAN LUIGI GESSA (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Drug and Alcohol Dependence (Rivista)

Insieme di parole chiave di

• Keywords of "Effect of the combination of naltrexone and baclofen on acquisition of alcohol drinking behavior in alcohol-preferring rats" (Insieme di parole chiave)