Endocannabinoid system and alcohol addiction: pharmacological studies. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Endocannabinoid system and alcohol addiction: pharmacological studies. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.pbb.2005.01.022 (literal)

Alternative label

• Colombo G., Serra S., Vacca G., Carai M.A.M., Gessa G.L. (2005)
  Endocannabinoid system and alcohol addiction: pharmacological studies.
  in Pharmacology, biochemistry and behavior
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Colombo G., Serra S., Vacca G., Carai M.A.M., Gessa G.L. (literal)

Pagina inizio

• 369 (literal)

Pagina fine

• 380 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 81 (literal)

Rivista

• Pharmacology, biochemistry and behavior (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• C.N.R. Institute of Neuroscience, Section of Cagliari, Cagliari, Italy; \"Bernard B. Brodie\" Department of Neuroscience, University of Cagliari, Cagliari, Italy (literal)

Titolo

• Endocannabinoid system and alcohol addiction: pharmacological studies. (literal)

Abstract

• The present paper describes the results of recent pharmacological studies implicating the cannabinoid CB1 receptor in the neural circuitry regulating alcohol consumption and motivation to consume alcohol. Cannabinoid CB1 receptor agonists have been found to specifically stimulate alcohol intake and alcohol's motivational properties in rats. Conversely, the cannabinoid CB1 receptor antagonist, SR 141716, has been reported to specifically suppress acquisition and maintenance of alcohol drinking behavior, relapse-like drinking and alcohol's motivational properties in rats. More recent data indicate that opioid receptor antagonists a) blocked the stimulatory effect of cannabinoids on alcohol intake, and b) synergistically potentiated the suppressing effect of SR 141716 on alcohol intake and alcohol's motivational properties. Consistently, SR 141716 blocked the stimulatory effect of morphine on alcohol intake. These results suggest a) the existence of a functional link between the cannabinoid and opioid receptor systems in the control of alcohol intake and motivation to consume alcohol, and b) that novel and potentially effective therapeutic strategies for alcoholism may come from the combination of cannabinoid and opioid receptor antagonists. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Autore CNR

• GIAN LUIGI GESSA (Unità di personale esterno)
• GIANCARLO COLOMBO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Endocannabinoid system and alcohol addiction: pharmacological studies." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• GIAN LUIGI GESSA (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Pharmacology, biochemistry and behavior (Rivista)

Insieme di parole chiave di

• Keywords of "Endocannabinoid system and alcohol addiction: pharmacological studies." (Insieme di parole chiave)