http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37773
Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -non preferring rats (Articolo in rivista)
- Type
- Label
- Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -non preferring rats (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.ejphar.2005.09.011 (literal)
- Alternative label
Castelli M.P., Pibiri F., Piras A.P., Carboni G., Orrù A., Gessa G.L., Carai M.A.M., Colombo G. (2005)
Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -non preferring rats
in European journal of pharmacology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Castelli M.P., Pibiri F., Piras A.P., Carboni G., Orrù A., Gessa G.L., Carai M.A.M., Colombo G. (literal)
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- ISI Web of Science (WOS) (literal)
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- Bernard B. Brodie Department of Neuroscience, University of Cagliari; CNR Institute of Neuroscience, Cagliari, Italy. (literal)
- Titolo
- Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -non preferring rats (literal)
- Abstract
- The function of the GABAB receptor, measured as baclofen-stimulated [35S]GTPgammaS binding, was evaluated in some brain regions of Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats. EC50 value of baclofen-stimulated 35SGTPgammaS in limbic areas was approximately 125% higher in alcohol-naive sP than sNP rats; voluntarily consumed alcohol reduced the EC50 value to a level similar to that of alcohol-naive sNP rats. These results suggest the presence of a genetically determined lower function of the GABAB receptor in limbic areas of sP than sNP rats; this differential functioning of the GABAB receptor may contribute to the opposite preference for alcohol in these rat lines. (literal)
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