Withdrawal syndrome from ƒgamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Withdrawal syndrome from ƒgamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.brainresprot.2005.04.001 (literal)

Alternative label

• Carai M.A.M., Quang L.S., Atzeri S., Lobina C., Maccioni P., Orrù A., Gessa G.L., Maher T.J., Colombo G. (2005)
  Withdrawal syndrome from ƒgamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats
  in Brain research protocols
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Carai M.A.M., Quang L.S., Atzeri S., Lobina C., Maccioni P., Orrù A., Gessa G.L., Maher T.J., Colombo G. (literal)

Pagina inizio

• 75 (literal)

Pagina fine

• 78 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Brain research protocols (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Neuroscience, University of Cagliari, Cagliari, Italy; Neuropharmacology and Neurobehavioral Laboratory, Division of Pediatric Pharmacology and Critical Care, Rainbow Babies and Children's Hospital, Cleveland, OH, USA; Department of Public Health, University of Cagliari, Cagliari, Italy; C.N.R. Institute of Neuroscience, Section of Cagliari, Cagliari, Italy; Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA. (literal)

Titolo

• Withdrawal syndrome from ƒgamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats (literal)

Abstract

• Gamma-hydroxybutyric acid (GHB) and its precursors, 1,4-butanediol (1,4-BD) and ?-butyrolactone (GBL), are recreational drugs widely abused in the U.S., Europe, and Australasia. A severe withdrawal syndrome from GHB, 1,4-BD and GBL has been increasingly documented over the last years, necessitating the development of a reliable animal model for investigations of potential therapeutic approaches. The present study describes the induction and occurrence of audiogenic seizures as a sign of withdrawal from GHB and 1,4-BD in selectively bred Sardinian alcohol-preferring (sP) rats, treated with escalating doses of GHB (1.5-3.5 g/kg, twice daily; i.g.) or 1,4-BD (500-1000 mg/kg, twice daily; i.g.) for 9 consecutive days. Acute administration of the selective GABAB receptor antagonist, SCH 50911, dramatically increased seizure occurrence. We propose that the inherent sensitivity of sP rats to different GHB-associated responses may have contributed to the unraveling of a phenomenon which was otherwise not recognizable in other rat strains. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Autore CNR

• GIANCARLO COLOMBO (Unità di personale interno)
• GIAN LUIGI GESSA (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Withdrawal syndrome from ƒgamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• GIAN LUIGI GESSA (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Brain research protocols (Rivista)

Insieme di parole chiave di

• Keywords of "Withdrawal syndrome from ƒgamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats" (Insieme di parole chiave)