Inhibition by miltirone of up-regulation of GABAA receptor alfa 4 subunit mRNA by ethanol withdrawal in hippocampal neurons (Articolo in rivista)

Type
Label
  • Inhibition by miltirone of up-regulation of GABAA receptor alfa 4 subunit mRNA by ethanol withdrawal in hippocampal neurons (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ejphar.2004.04.021 (literal)
Alternative label
  • Mostallino M.C.; Mascia M.P.; Pisu M.G.; Busonero F.; Talani G.; Biggio G (2004)
    Inhibition by miltirone of up-regulation of GABAA receptor alfa 4 subunit mRNA by ethanol withdrawal in hippocampal neurons
    in European journal of pharmacology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mostallino M.C.; Mascia M.P.; Pisu M.G.; Busonero F.; Talani G.; Biggio G (literal)
Pagina inizio
  • 83 (literal)
Pagina fine
  • 90 (literal)
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  • 494 (literal)
Rivista
Note
  • Scopu (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Section of Neuropsychopharmacology, CNR Institute of Neuroscience, University of Cagliari, Cagliari, Italy Centre of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Italy (literal)
Titolo
  • Inhibition by miltirone of up-regulation of GABAA receptor alfa 4 subunit mRNA by ethanol withdrawal in hippocampal neurons (literal)
Abstract
  • Miltirone, a tanshinone isolated from the root of Salvia miltiorrhiza, has been characterized as a low-affinity ligand for central benzodiazepine receptors. We have now shown that this compound bound with low affinity (micromolar range) to central benzodiazepine recognition sites but did not interact with peripheral benzodiazepine receptors. It failed to potentiate Cl(-) currents induced by gamma-aminobutyric acid (GABA) both in Xenopus oocytes expressing recombinant human GABA(A) receptors and in cultured rat hippocampal pyramidal cells, but it inhibited the ability of diazepam to potentiate the effect of GABA in these systems. Miltirone (1-10 microM) also partially inhibited the increase in the abundance of the mRNA for the alpha(4) subunit of the GABA(A) receptor induced by ethanol withdrawal in cultured hippocampal neurons. These results suggest that miltirone might ameliorate the symptoms associated with discontinuation of long-term administration of ethanol or of other positive modulators of the GABA(A) receptor. (literal)
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