Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knock out mice. (Articolo in rivista)

Type
Label
  • Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knock out mice. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • Nicola Kuczewski, Eugenio Aztiria, Dinesh Gautam, Jurgen Wess, Luciano Domenici (2005)
    Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knock out mice.
    in Journal of physiology (Lond., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Nicola Kuczewski, Eugenio Aztiria, Dinesh Gautam, Jurgen Wess, Luciano Domenici (literal)
Pagina inizio
  • 907 (literal)
Pagina fine
  • 919 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 566 (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Nicola Kuczewski, Eugenio Aztiria, Luciano Domenici: Cognitive Neuroscience Sector, International School for Advanced Studies (S.I.S.S.A), Trieste 34014, Italy. Dinesh Gautam, Jurgen Wess: Molecular Signalling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. Luciano Domenici: Institute of Neuroscience, CNR, 56100 Pisa, Italy. (literal)
Titolo
  • Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knock out mice. (literal)
Abstract
  • The central cholinergic system plays a crucial role in synaptic plasticity and spatial attention; however, the roles of the individual cholinergic receptors involved in these activities are not well understood at present. In the present study, we show that acetylcholine (ACh) can facilitate or depress synaptic transmission in occipital slices of mouse visual cortex. The precise nature of the ACh effects depends on the ACh concentration, and is input specific, as shown by stimulating different synaptic pathways. Pharmacological blockade of muscarinic receptor (mAChR) subtypes and the use of M1-M5mAChR-deficient mice showed that specific mAChR subtypes, together with the activity of the cholinesterases (ChEs), mediate facilitation or depression of synaptic transmission. The present data suggest that local ACh, acting through mAChRs, regulates the cortical dynamics making cortical circuits respond to specific stimuli. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it