http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37680
Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase. (Articolo in rivista)
- Type
- Label
- Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase. (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bbrc.2006.03.050 (literal)
- Alternative label
Rigobello MP, Vianello F, Folda A, Roman C, Scutari G, Bindoli A (2006)
Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase.
in Biochemical and biophysical research communications (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Rigobello MP, Vianello F, Folda A, Roman C, Scutari G, Bindoli A (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Chimica Biologica, Universita` di Padova, Viale G. Colombo 3, 35121 Padova, Italy
Istituto di Neuroscienze (CNR), Sezione di Biomembrane c/o Dipartimento di Chimica Biologica, Viale G. Colombo 3, 35121 Padova, Italy (literal)
- Titolo
- Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase. (literal)
- Abstract
- The effect of calcium ions has been studied on three different isoforms of thioredoxin reductase. The cytosolic (TrxR1), mitochondrial
(TrxR2), and the Escherichia coli enzymes were examined and compared. In our condition, TrxR1 appears extremely sensitive to Ca2+
showing an IC50 of about 160 nM, while Ca2+ exerts only a weak inhibitory effect on the mitochondrial isoform. The thioredoxin reductase
purified from E. coli is almost completely insensitive to calcium ions. Circular dichroism analysis of highly purified mitochondrial
and cytosolic thioredoxin reductases reveals that Ca2+ induces conformational alterations that are particularly relevant only in the cytosolic
isoform. These observations are discussed with reference to the physiological role and, in particular, to the regulatory functions of
the thioredoxin system. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi