Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.euroneuro.2003.08.002 (literal)

Alternative label

• Biggio G. 1, Dazzi L. 1, Biggio F. 1, Mancuso L. 1, Talani G. 1, Busonero F. 1, Mostallino M.C. 2, Sanna E. 1, Follesa P. 1 (2003)
  Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators.
  in European neuropsychopharmacology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Biggio G. 1, Dazzi L. 1, Biggio F. 1, Mancuso L. 1, Talani G. 1, Busonero F. 1, Mostallino M.C. 2, Sanna E. 1, Follesa P. 1 (literal)

Pagina inizio

• 411 (literal)

Pagina fine

• 423 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 13(6) (literal)

Rivista

• European neuropsychopharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 23 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Experimental Biology, Center of Excellence for the Neurobiology of Dependence, University of Cagliari, Cagliari, Institute of Neuroscience, CNR, Cagliari (literal)

Titolo

• Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators. (literal)

Abstract

• Here, we summarize recent data pertaining to the effects of GABA(A) receptor modulators on the receptor gene expression in order to elucidate the molecular mechanisms behind tolerance and dependence induced by these drugs. Drug selectivity and intrinsic activity seems to be important to evidence at the molecular level the GABA(A) receptor tolerance. On the contrary, we suggested that all drug tested are equally potentially prone to induce dependence. Our results demonstrate that long-lasting exposure of GABA(A) receptors to endogenous steroids, benzodiazepines and ethanol, as well as their withdrawal, induce marked effects on receptor structure and function. These results suggest the possible synergic action between endogenous steroids and these drugs in modulating the functional activity of specific neuronal populations. We report here that endogenous steroids may play a crucial role in the action of ethanol on dopaminergic neurons. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Autore CNR

• GIUSEPPE TALANI (Persona)
• MARIA CRISTINA MOSTALLINO (Persona)

Insieme di parole chiave

• Keywords of "Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA CRISTINA MOSTALLINO (Persona)
• GIUSEPPE TALANI (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European neuropsychopharmacology (Rivista)

Insieme di parole chiave di

• Keywords of "Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators." (Insieme di parole chiave)