Provision of brain-derived neurotrophic factor via anterograde transport from the eye preserves the physiological responses of axotomized geniculate neurons. (Articolo in rivista)

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  • Provision of brain-derived neurotrophic factor via anterograde transport from the eye preserves the physiological responses of axotomized geniculate neurons. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Caleo M, Medini P, von Bartheld CS, Maffei L. (2003)
    Provision of brain-derived neurotrophic factor via anterograde transport from the eye preserves the physiological responses of axotomized geniculate neurons.
    in The Journal of neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Caleo M, Medini P, von Bartheld CS, Maffei L. (literal)
Pagina inizio
  • 287 (literal)
Pagina fine
  • 296 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • IF= 8 La internazionalità e notorietà di questo lavoro è garantita dalla rivista stessa su cui è stato pubblicato, che è una rivista di grande diffusione ed importanza. Il lavoro è di interesse sia per studiosi nel campo della neurobiologia che in quello della Neurologia, con particolare riferimento alle malattie neurodegenerative. (literal)
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  • 23 (literal)
Rivista
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  • I FATTORI NEUROTROFICI SONO CANDIDATI PER IL TRATTAMENTO DELLE PATOLOGIE NEURODEGENERATIVE. IN QUESTO LAVORO SI DIMOSTRA CHE LA SOMMINISTRAZIONE DEL FATTORE TROFICO BDNF AI NUCLEI TALAMICI DEL RATTO PREVIENE LA DEGENERAZIONE NEURONALE DOPO UNA LESIONE. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • N. 1 Istituto di Neuroscienze CNR Pisa, N. 2 SCUOLA NORMALE SUPERIORE Pisa, N. 1 UNIVERSITY OF NEVADA (literal)
Titolo
  • Provision of brain-derived neurotrophic factor via anterograde transport from the eye preserves the physiological responses of axotomized geniculate neurons. (literal)
Abstract
  • The neurotrophic factors of the nerve growth factor family (neurotrophins) have been shown to promote neuronal survival after brain injury and in various models of neurodegenerative conditions. However, it has not been determined whether neurotrophin treatment results in the maintenance of function of the rescued cells. Here we have used the retrograde degeneration of geniculate neurons as a model system to evaluate neuronal rescue and sparing of function after administration of brain-derived neurotrophic factor (BDNF). Death of geniculate neurons was induced by a visual cortex lesion in adult rats, and exogenous BDNF was delivered to the axotomized geniculate cells via anterograde transport after injection into the eye. By microelectrode recordings from the geniculate in vivo we have measured several physiological parameters such as contrast threshold, spatial resolution (visual acuity), signal-to-noise ratio, temporal resolution, and response latency. In control lesioned animals we found that geniculate cell dysfunction precedes the onset of neuronal death, indicating that an assessment of neuronal number per se is not predictive of functional performance. The administration of BDNF resulted in a highly significant cell-saving effect up to 2 weeks after the cortical damage and maintained nearly normal physiological responses in the geniculate. This preservation of function in adult axotomized neurons suggests possible therapeutic applications of BDNF. (literal)
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