http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37529

Blockade of A(2A) receptors plus L-DOPA after nigrostriatal lesion results in GAD67 mRNA changes different from L-DOPA alone in the rat globus pallidus and substantia nigra reticulata (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Blockade of A(2A) receptors plus L-DOPA after nigrostriatal lesion results in GAD67 mRNA changes different from L-DOPA alone in the rat globus pallidus and substantia nigra reticulata (Articolo in rivista) (literal)

Anno

2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/S0014-4886(03)00292-9 (literal)

Alternative label

Carta, AR; Tabrizi, MA; Baraldi, PG; Pinna, A; Pala, P; Morelli, M (2003)
Blockade of A(2A) receptors plus L-DOPA after nigrostriatal lesion results in GAD67 mRNA changes different from L-DOPA alone in the rat globus pallidus and substantia nigra reticulata
in Experimental neurology; Elsevier Inc., San Diego (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Carta, AR; Tabrizi, MA; Baraldi, PG; Pinna, A; Pala, P; Morelli, M (literal)

Pagina inizio

679 (literal)

Pagina fine

687 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

184 (literal)

Rivista

Experimental neurology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

ISI Web of Science (WOS) (literal)
ISI Web of Science (WoS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

University of Cagliari; University of Cagliari; University of Ferrara; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

Blockade of A(2A) receptors plus L-DOPA after nigrostriatal lesion results in GAD67 mRNA changes different from L-DOPA alone in the rat globus pallidus and substantia nigra reticulata (literal)

Abstract

Studies in animal models of Parkinson's disease (PD) suggest the potential utility of adenosine A2A antagonists in the treatment of this disease. In the present study, unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats received chronic intermittent treatment with the adenosine A(2A) antagonist SCH58261 (5 mg/kg) plus L-DOPA (3 mg/kg) or L-DOPA (6 mg/kg) alone, at doses producing the same intensity of contralateral turning on first administration. Three days after discontinuation of treatments, GABA synthesizing enzyme glutamic acid decarboxylase (GAD67) mRNA was evaluated at cellular level in the globus pallidus (GP) and substantia nigra pars reticulata (SNr) by in situ hybridization. 6-OHDA lesion significantly increased GAD67 mRNA levels in both the GP and SNr ipsilateral to the lesion. Chronic L-DOPA (6 mg/kg), in contrast to SCH58261 Plus L-DOPA (3 mg/kg), produced a sensitized contralateral turning indicative of dyskinetic potential and further increased GAD67 mRNA in the GP. In the SNr, a significant decrease in GAD67 mRNA was observed after either treatments. However, while L-DOPA (6 mg/kg) decreased SNr GAD67 mRNA below the intact side, SCH58261 PIUS L-DOPA (3 mg/kg) brought GAD67 mRNA to the same level of the intact SNr. L-DOPA (3 mg/kg) or SCH58261 (5 mg/kg) alone failed to modify GAD67 mRNA. Results suggest that an increase in GAD67 mRNA in GP and a decrease in SNr might underlie dyskinetic movements induced by chronic L-DOPA. In contrast, the lack of GAD67 mRNA changes in the GP and a less marked inhibition of SNr might correlate with the absence of dyskinetic potential observed after SCH58261 Plus L-DOPA. (C) 2003 Elsevier Inc. All rights reserved. (literal)

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