http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37465
The strain-specific involvement of nucleus accumbens in latent inhibition might depend on differences in processing configural- and cue-based information between C57BL/6 and DBA/2 mice (Articolo in rivista)
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- The strain-specific involvement of nucleus accumbens in latent inhibition might depend on differences in processing configural- and cue-based information between C57BL/6 and DBA/2 mice (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Restivo L., Passino E., Middei S., Ammassari-Teule M. (2002)
The strain-specific involvement of nucleus accumbens in latent inhibition might depend on differences in processing configural- and cue-based information between C57BL/6 and DBA/2 mice
in Brain research bulletin
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- Restivo L., Passino E., Middei S., Ammassari-Teule M. (literal)
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- Titolo
- The strain-specific involvement of nucleus accumbens in latent inhibition might depend on differences in processing configural- and cue-based information between C57BL/6 and DBA/2 mice (literal)
- Abstract
- Latent inhibition (LI) consists in decreased associative strength between
an elemental stimulus (CS: tone) paired with an unconditioned stimulus
(US: footshock) following non reinforced pre-exposure to the tone. In view
of the differences shown by C57BL/6 (C57) and DBA/2 (DBA) mice in
processing elemental vs configural stimuli, the present experiments were
designed (1) to assess whether these differences were susceptible to
interfere with the capability of each strain to show LI. and (2) to verify
the extent to which lesions of the nucleus accumbens, that have been
reported to enhance attention towards contextual stimuli under certain
conditions, might interfere with the development of LI. C57 and DBA mice
with Nacc- or sham- lesions were given two periods (4 or 7 days) of pre-
exposure to a CS (tone) then subjected to two CS-US pairings given on a
single day. On the day after, freezing to the tone was examined in each
group. Results show that, following the shorter period of pre-exposure, LI
developed in sham-lesioned DBA but did not in sham-lesioned C57. Nacc
lesions, however, were found (1) to block LI in DBA but (2) to promote LI
in C57. After the longer period of pre-exposure LI was observed in both
strain and lesion conditions. In general, these results confirm that
strain differences in processing the tone as a single elemental cue (DBA)
or, alternatively, as a part of a contextual configural stimulus (C57) can
interfere with the development of LI. In addition, they indicate that Nacc
lesions, that are susceptible to increase attention to the background,
might modify the salience of the tone and produce opposite effect on LI
according to the strain specialisation to show elemental or configural
responding. (literal)
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