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Effects of MK-801 and ethanol combinations on memory consolidation in CD1 mice: involvement of gabaergic mechanisms. (Articolo in rivista)
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- Effects of MK-801 and ethanol combinations on memory consolidation in CD1 mice: involvement of gabaergic mechanisms. (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Aversano M., Ciamei A., Cestari C., Passino E., Middei S., Castellano C. (2002)
Effects of MK-801 and ethanol combinations on memory consolidation in CD1 mice: involvement of gabaergic mechanisms.
in Neurobiology of learning and memory (Print)
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- Aversano M., Ciamei A., Cestari C., Passino E., Middei S., Castellano C. (literal)
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- Titolo
- Effects of MK-801 and ethanol combinations on memory consolidation in CD1 mice: involvement of gabaergic mechanisms. (literal)
- Abstract
- In the present research the effect of the noncompetitive N-methyl-d-aspartate
receptor antagonist MK-801 and ethanol combinations on memory consolidation
and the involvement of GABAergic mechanisms in this effect were investigated in
CD1 mice injected intraperitoneally with the drugs immediately or 120 min after
training in a one-trial inhibitory avoidance apparatus and tested for retention 24 h
later. The results showed that (a) the retention performances of mice were impaired
in a dose-dependent manner by immediate posttraining MK-801 (0.2 and 0.3, but
not 0.1 mg/kg) and ethanol (1 and 2, but not 0.5 g/kg) administrations; (b) an
otherwise ineffective dose of MK-801 (0.1 mg/kg) enhanced the deleterious effect
exerted by ethanol (1 and 2 g/kg); (c) an otherwise ineffective dose of muscimol
(0.5 mg/kg) enhanced, while otherwise ineffective doses of picrotoxin (0.25 mg/kg)
or bicuculline (0.1 mg/kg) antagonized, this effect; and (d) no effect was observed
when the treatments were carried out 120 min after training, suggesting that the
effects observed following immediate posttraining administrations were due to the
influence on the consolidation of memory. From these experiments it is evident that
(a) MK-801 enhances ethanol's effects on memory consolidation and (b)
GABAergic mechanisms are involved in this effect. Copyright 2001 Elsevier
Science (USA). (literal)
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