The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Mara Marongiu,1; Manila Deiana,1; Alessandra Meloni,1; Loredana Marcia,1; Alessandro Puddu,1,2; Antonio Cao,1; David Schlessinger,3; Laura Crisponi1* (2010)
  The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mara Marongiu,1; Manila Deiana,1; Alessandra Meloni,1; Loredana Marcia,1; Alessandro Puddu,1,2; Antonio Cao,1; David Schlessinger,3; Laura Crisponi1* (literal)

Rivista

• PloS one (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy 2Università degli Studi di Cagliari, Cagliari, Italy 3National Institute on Aging, National Institiutes of Health, Baltimore, Maryland, United States of America (literal)

Titolo

• The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. (literal)

Abstract

• The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure. Inactivation of Foxl2 in mice demonstrated its indispensability for female gonadal sex determination and ovary development and revealed its antagonism of Sox9, the effector of male testis development. To help to define the regulatory activities of FOXL2, we looked for interacting proteins. Based on yeast two-hybrid screening, we found that FOXL2 interacts with PIAS1 and UBC9, both parts of the sumoylation machinery. We showed that human FOXL2 is sumoylated in transfected cell lines, and that endogenous mouse Foxl2 is comparably sumoylated. This modification changes its cellular localization, stability and transcriptional activity. It is intriguing that similar sumoylation and regulatory consequences have also been reported for SOX9, the male counterpart of FOXL2 in somatic gonadal tissues. (literal)

Prodotto di

• Meccanismi patogenetici alla base di malattie sindromiche (ME.P05.009.001) (Modulo)
• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)

Autore CNR

• ALESSANDRA MELONI (Persona)
• LAURA CRISPONI (Persona)
• MARA MARONGIU (Persona)
• LOREDANA MARCIA (Persona)
• MANILA DEIANA (Unità di personale interno)
• ANTONIO CAO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)
• Meccanismi patogenetici alla base di malattie sindromiche (ME.P05.009.001) (Modulo)

Autore CNR di

• LAURA CRISPONI (Persona)
• MANILA DEIANA (Unità di personale interno)
• LOREDANA MARCIA (Persona)
• ALESSANDRA MELONI (Persona)
• ANTONIO CAO (Unità di personale interno)
• MARA MARONGIU (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)