http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37326
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (Articolo in rivista)
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- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, et al (2011)
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
in Nature genetics (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, et al (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
2Imperial College Healthcare National Health Service (NHS) Trust, London, UK
3Ealing Hospital NHS Trust, Middlesex, UK
4National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
5Institute of Clinical Science, Imperial College London, Royal Brompton Hospital, London, UK
6Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, South Kensington, London, UK
7Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
8deCODE genetics, Reykjavik, Iceland
9Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy
10Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
11Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands
12Institute for Community Medicine, University of Greifswald, Germany
13Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China
14Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
15Department of Neurology, Boston University School of Medicine, Boston Massachusetts, USA
16Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands
17Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
18Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
19Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
20Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
21Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
22Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
23Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge UK
24Institute of Social and Preventive Medicine (IUMSP), University Hospital and University of Lausanne, Lausanne, Switzerland
25Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
26Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland
27Nuclear Magnetic Resonance (NMR) Metabonomics Laboratory, Department of Biosciences, University of Eastern Finland, Kuopio, Finland
28Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA
29Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA
30Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
31Boston University School of Medicine, Boston, Massachusetts, USA
32Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA
33The Diabetes Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK
34Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
35Neuroscience Campus Amsterdam, VUA and VUA Medical Center, Amsterdam, The Netherlands
36National Heart and Lung Institute, Imperial College London, London, UK
37Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
38Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
39IUMSP, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
40Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
41The Laboratory in Mjodd, Reykjavik, Iceland
42Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
43Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany
44Genetics and Gastroenterology Divisions, Brigham and Women's Hospital, Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
45Harvard Medical School, Boston, Massachusetts, USA
46Harvard Stem Cell Institute, Cambridge, Massachusetts, USA
47Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, US National Institutes of Health (NIH), Bethesda, Maryland, USA
48Institute of Clinical Medicine, University of Oulu, Oulu, Finland
49CEA-IG Centre National de Genotypage, Evry Cedex, France
50Department of Medicine, University of Toronto, Toronto, Ontario, Canada
51Liver Center, Toronto Western Hospital, Toronto, Ontario, Canada
52Centre for Liver Research, University of Birmingham, Birmingham, UK
53Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany
54Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
55Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
56Clinical Pharmacology and The Genome Center, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
57Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
58Institute of Diagnostic Radiology and Neuroradiology, University of Greifswald, Greifswald, Germany
59Fondation Jean Dausset Ceph, Paris, France
60Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
61Department of Genetics, Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA
62Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA
63Office of Biostatistics Research, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
64Queensland Institute of Medical Research, Brisbane, Queensland, Australia
65Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
66Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
67Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
68Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
69NHLBI Framingham Heart Study, Framingham, Massachusetts, USA
70Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland
71Department of Psychiatry and EMGO Institute for Health and Care Research, VUA Medical Centre, Amsterdam, The Netherlands
72Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
73Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
74Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland
75Institute of Diagnostics, Clinical Chemistry, University of Oulu, Oulu, Finland
76Department of Internal Medicine and Biocenter Oulu, Clinical Research Center, University of Oulu, Oulu, Finland
77Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA
78Gesellschaft für Arterioskleroseforschung, Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany
79Department of Immunology, University of Toronto, Toronto, Ontario, Canada
80Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
81Mount Sinai Hospital Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
82Toronto General Research Institute, Toronto, Ontario, Canada
83Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
84Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
85Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
86Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
87LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
88Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA
89Cardiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
90Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
91Klinikum Grosshadern, Munich, Germany
92EMGO+Institute, VUA Medical Center, Amsterdam, The Netherlands
93Samuel Lunenfeld and Toronto General Research Institutes, Toronto, Ontario, Canada
94Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
96Center for Medical Systems Biology, Rotterdam, The Netherlands
97Genomics of Common Diseases, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK
98Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK
99Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
100Obesity Research Unit, Department of Medicine, Division of Internal Medicine, Helsinki University Hospital, Helsinki, Finland
101The Institute for Molecular Medicine FIMM, Helsinki, Finland
102Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland
103MRC-Social Genetic Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, King's College, London, UK
104Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
105Faculty of Medicine, Imperial College London, London, UK
106Faculty of Medicine, University of Iceland, Reykjavik, Iceland
107Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
108Division of Endocrinology, Hypertension, and Metabolism, Brigham and Women's Hospital, Boston, Massachusetts, USA
109Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA
110Institute of Health Sciences, University of Oulu, Oulu, Finland
111Biocenter Oulu, University of Oulu, Oulu, Finland
112MRC-Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK (literal)
- Titolo
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (literal)
- Abstract
- Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10-8 to P = 10-190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function. (literal)
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