Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (Articolo in rivista)

Type
Label
  • Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cathy E. Elks,1*; John R.B. Perry,2*; Patrick Sulem,3*; Daniel I. Chasman,4,5; Nora Franceschini,6; Chunyan He,7,8; Kathryn L. Lunetta,9,10; Jenny A. Visser,11; Enda M. Byrne,12,13; Diana L. Cousminer,14; Daniel F. Gudbjartsson,3; Tõnu Esko,15,16,17; Bjarke Feenstra,18; Jouke-Jan Hottenga,19; Daniel L. Koller,20; Zoltán Kutalik,21,22; Peng Lin,23; Massimo Mangino,24; Mara Marongiu,25; Patrick F. McArdle,26; Albert V. Smith,27,28; Lisette Stolk,11,29; Sophie W. van Wingerden,30; Jing Hua Zhao,1; Eva Albrecht,31; Tanguy Corre,32; Erik Ingelsson,33; Caroline Hayward,34; Patrik K.E. Magnusson,33; Erin N. Smith,35; Shelia Ulivi,36; Nicole M. Warrington,37; Lina Zgaga,38; Helen Alavere,15; Najaf Amin,30; Thor Aspelund,27,28; Stefania Bandinelli,39; Ines Barroso,40; Gerald S. Berenson,41; Sven Bergmann,21,22; Hannah Blackburn,40; Eric Boerwinkle,42; Julie E. Buring,4,43; Fabio Busonero,25; Harry Campbell,38; Stephen J. Chanock,44; Wei Chen,41; Marilyn C. Cornelis,45; David Couper,46; Andrea D. Coviello,47; Pio d'Adamo,36; Ulf de Faire,48; Eco J.C. de Geus,19; Panos Deloukas,40; Angela Döring,31; George Davey Smith,49; Douglas F. Easton,50; Gudny Eiriksdottir,27; Valur Emilsson,51; Johan Eriksson,52,53,54,55; Luigi Ferrucci,56; Aaron R. Folsom,57; Tatiana Foroud,20; Melissa Garcia,58; Paolo Gasparini,36; Frank Geller,18; Christian Gieger,31; The GIANT Consortium,59; Vilmundur Gudnason,27,28; Per Hall,33; Susan E. Hankinson,43,60; Liana Ferreli,25; Andrew C. Heath,61; Dena G. Hernandez,62; Albert Hofman,63; Frank B. Hu,43,45,60; Thomas Illig,31; Marjo-Riitta Järvelin,64; Andrew D. Johnson,9,65; David Karasik,66; Kay-Tee Khaw,67; Douglas P. Kiel,66; Tuomas O. Kilpeläinen,1; Ivana Kolcic,68; Peter Kraft,43,45,60; Lenore J. Launer,58; Joop S.E. Laven,69; Shengxu Li,1; Jianjun Liu,70; Daniel Levy,9,65,71; Nicholas G. Martin,72; Wendy L. McArdle,73; Mads Melbye,18; Vincent Mooser,74; Jeffrey C. Murray,75; Sarah S. Murray,35; Michael A. Nalls,76; Pau Navarro,34; Mari Nelis,15,16,17; Andrew R. Ness,77; Kate Northstone,73; Ben A. Oostra,30; Munro Peacock,78; Lyle J. Palmer,37; Aarno Palotie,14,40,79; Guillaume Paré,4,5,80; Alex N. Parker,81; Nancy L. Pedersen,33; Leena Peltonen,14,40,52,79,82; Craig E. Pennell,83; Paul Pharoah,50; Ozren Polasek,68,84; Andrew S. Plump,85; Anneli Pouta,52; Eleonora Porcu,25; Thorunn Rafnar,3, John P. Rice,23; Susan M. Ring,73; Fernando Rivadeneira,11,29,63; Igor Rudan,38,86; Cinzia Sala,32; Veikko Salomaa,52; Serena Sanna,25; David Schlessinger,87; Nicholas J. Schork,35; Angelo Scuteri,25,88; Ayellet V. Segrè,79,89; Alan R. Shuldiner,26,90; Nicole Soranzo,24,40; Ulla Sovio,64; Sathanur R. Srinivasan,41; David P. Strachan,91; Mar-Liis Tammesoo,15; Emmi Tikkanen,14,52; Daniela Toniolo,32; Kim Tsui,81; Laufey Tryggvadottir,92; Jonathon Tyrer,50; Manuela Uda,25; Rob M. van Dam,45,93; Joyve B.J. van Meurs,11; Peter Vollenweider,94; Gerard Waeber,94; Nicholas J. Wareham,1; Dawn M. Waterworth,74; Michael N. Weedon,2; H. Erich Wichmann,31,95,96; Gonneke Willemsen,19; James F. Wilson,38; Alan F. Wright,34; Lauren Young,81; Guangju Zhai,24; Wei Vivian Zhuang,10; Laura J. Bierut,23; Dorret I. Boomsma,19; Heather A. Boyd,18; Laura Crisponi,25; Ellen W. Demerath,57; Cornelia M. van Duijn,30; Michael J. Econs,20,78; Tamara B. Harris,58; David J. Hunter,43,44,45,60; Ruth J.F. Loos,1; Andres Metspalu,15,16,17; Grant W. Montgomery,97; Paul M. Ridker,4,5,43,98; Tim D. Spector,24; Elizabeth A. Streeten,26; Kari Stefansson,3,99; Unnur Thorsteinsdottir,3,99; André G. Uitterlinden,11,29,63; Elisabeth Widen,14; Joanne M. Murabito,9,47**; Ken Ong,1,100** ; Anna Murray2** (2010)
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cathy E. Elks,1*; John R.B. Perry,2*; Patrick Sulem,3*; Daniel I. Chasman,4,5; Nora Franceschini,6; Chunyan He,7,8; Kathryn L. Lunetta,9,10; Jenny A. Visser,11; Enda M. Byrne,12,13; Diana L. Cousminer,14; Daniel F. Gudbjartsson,3; Tõnu Esko,15,16,17; Bjarke Feenstra,18; Jouke-Jan Hottenga,19; Daniel L. Koller,20; Zoltán Kutalik,21,22; Peng Lin,23; Massimo Mangino,24; Mara Marongiu,25; Patrick F. McArdle,26; Albert V. Smith,27,28; Lisette Stolk,11,29; Sophie W. van Wingerden,30; Jing Hua Zhao,1; Eva Albrecht,31; Tanguy Corre,32; Erik Ingelsson,33; Caroline Hayward,34; Patrik K.E. Magnusson,33; Erin N. Smith,35; Shelia Ulivi,36; Nicole M. Warrington,37; Lina Zgaga,38; Helen Alavere,15; Najaf Amin,30; Thor Aspelund,27,28; Stefania Bandinelli,39; Ines Barroso,40; Gerald S. Berenson,41; Sven Bergmann,21,22; Hannah Blackburn,40; Eric Boerwinkle,42; Julie E. Buring,4,43; Fabio Busonero,25; Harry Campbell,38; Stephen J. Chanock,44; Wei Chen,41; Marilyn C. Cornelis,45; David Couper,46; Andrea D. Coviello,47; Pio d'Adamo,36; Ulf de Faire,48; Eco J.C. de Geus,19; Panos Deloukas,40; Angela Döring,31; George Davey Smith,49; Douglas F. Easton,50; Gudny Eiriksdottir,27; Valur Emilsson,51; Johan Eriksson,52,53,54,55; Luigi Ferrucci,56; Aaron R. Folsom,57; Tatiana Foroud,20; Melissa Garcia,58; Paolo Gasparini,36; Frank Geller,18; Christian Gieger,31; The GIANT Consortium,59; Vilmundur Gudnason,27,28; Per Hall,33; Susan E. Hankinson,43,60; Liana Ferreli,25; Andrew C. Heath,61; Dena G. Hernandez,62; Albert Hofman,63; Frank B. Hu,43,45,60; Thomas Illig,31; Marjo-Riitta Järvelin,64; Andrew D. Johnson,9,65; David Karasik,66; Kay-Tee Khaw,67; Douglas P. Kiel,66; Tuomas O. Kilpeläinen,1; Ivana Kolcic,68; Peter Kraft,43,45,60; Lenore J. Launer,58; Joop S.E. Laven,69; Shengxu Li,1; Jianjun Liu,70; Daniel Levy,9,65,71; Nicholas G. Martin,72; Wendy L. McArdle,73; Mads Melbye,18; Vincent Mooser,74; Jeffrey C. Murray,75; Sarah S. Murray,35; Michael A. Nalls,76; Pau Navarro,34; Mari Nelis,15,16,17; Andrew R. Ness,77; Kate Northstone,73; Ben A. Oostra,30; Munro Peacock,78; Lyle J. Palmer,37; Aarno Palotie,14,40,79; Guillaume Paré,4,5,80; Alex N. Parker,81; Nancy L. Pedersen,33; Leena Peltonen,14,40,52,79,82; Craig E. Pennell,83; Paul Pharoah,50; Ozren Polasek,68,84; Andrew S. Plump,85; Anneli Pouta,52; Eleonora Porcu,25; Thorunn Rafnar,3, John P. Rice,23; Susan M. Ring,73; Fernando Rivadeneira,11,29,63; Igor Rudan,38,86; Cinzia Sala,32; Veikko Salomaa,52; Serena Sanna,25; David Schlessinger,87; Nicholas J. Schork,35; Angelo Scuteri,25,88; Ayellet V. Segrè,79,89; Alan R. Shuldiner,26,90; Nicole Soranzo,24,40; Ulla Sovio,64; Sathanur R. Srinivasan,41; David P. Strachan,91; Mar-Liis Tammesoo,15; Emmi Tikkanen,14,52; Daniela Toniolo,32; Kim Tsui,81; Laufey Tryggvadottir,92; Jonathon Tyrer,50; Manuela Uda,25; Rob M. van Dam,45,93; Joyve B.J. van Meurs,11; Peter Vollenweider,94; Gerard Waeber,94; Nicholas J. Wareham,1; Dawn M. Waterworth,74; Michael N. Weedon,2; H. Erich Wichmann,31,95,96; Gonneke Willemsen,19; James F. Wilson,38; Alan F. Wright,34; Lauren Young,81; Guangju Zhai,24; Wei Vivian Zhuang,10; Laura J. Bierut,23; Dorret I. Boomsma,19; Heather A. Boyd,18; Laura Crisponi,25; Ellen W. Demerath,57; Cornelia M. van Duijn,30; Michael J. Econs,20,78; Tamara B. Harris,58; David J. Hunter,43,44,45,60; Ruth J.F. Loos,1; Andres Metspalu,15,16,17; Grant W. Montgomery,97; Paul M. Ridker,4,5,43,98; Tim D. Spector,24; Elizabeth A. Streeten,26; Kari Stefansson,3,99; Unnur Thorsteinsdottir,3,99; André G. Uitterlinden,11,29,63; Elisabeth Widen,14; Joanne M. Murabito,9,47**; Ken Ong,1,100** ; Anna Murray2** (literal)
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  • 1 Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK 2 Genetics of Complex Traits, Peninsula Medical School, University of Exeter, UK 3 deCODE Genetics, Reykjavik, Iceland 4 Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston MA 02215, USA 5 Harvard Medical School, Boston, Massachusetts, USA 6 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 7 Department of Public Health, Indiana University School of Medicine, Indiana, USA 8 Melvin and Bren Simon Cancer Center, Indiana University, Indiana, USA 9 The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA 10 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA 11 Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands 12 Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia 13 The University of Queensland, Brisbane, Australia 14 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland 15 Estonian Genome Center, University of Tartu, Tartu, Estonia 16 Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia 17 Genotyping Core Facility, Estonian Biocenter, Tartu, Estonia 18 Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark 19 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands 20 Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana, USA 21 Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland 22 Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland 23 Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA 24 Department of Twin Research and Genetic Epidemiology, King's College London, London, UK 25 Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy 26 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA 27 Icelandic Heart Association, Kopavogur, Iceland 28 University of Iceland, Reykjavik, Iceland 29 Netherlands Consortium of Healthy Aging, Rotterdam, the Netherlands 30 Genetic-Epidemiology Unit, Department of Epidemiology and Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands 31 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany 32 Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy 33 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden 34 MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine, Western General Hospital; Edinburgh, UK 35 Scripps Genomic Medicine, The Scripps Translational Science Institute, and The Scripps Research Institute, La Jolla, CA, USA 36 Medical Genetics, Department of Reproductive Sciences and Development, University of Trieste, Trieste, Italy 37 Centre for Genetic Epidemiology and Biostatistics University of Western Australia, Australia 38 Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland 39 Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy 40 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK 41 Tulane University, New Orleans, LA, USA 42 Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA 43 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA 44 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA 45 Department of Nutrition, Harvard School of Public Health, Boston, MA, USA 46 Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 47 Sections of General Internal Medicine, Preventive Medicine and Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA 48 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 49 MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, BS8 2BN, UK 50 Centre for Cancer Genetic Epidemiology, Departments of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, UK 51 MPRI, Merck & Co., Inc, 126 Lincoln Ave, Rahway, NJ 07065, USA 52 National Institute for Health and Welfare, Finland 53 Department of General Practice and Primary health Care, University of Helsinki, Finland 54 Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland 55 Folkhalsan Research Centre, Helsinki, Finland 56 Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA 57 Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA 58 Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA 60 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA 61 Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA 62 Laboratory of Neurogenetics, National Institute of Ageing, Bethesda, MD, USA 63 Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands 64 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK 65 NHLBI Center for Population Studies, Bethesda, MD, USA 66 Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA 67 Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB2 0QQ, UK 68 Medical School; University of Zagreb; Zagreb, 10000; Croatia 69 Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands 70 Human Genetics, Genome Institute of Singapore, Singapore 71 Division of Cardiology, Boston University School of Medicine, USA 72 Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia 73 Avon Longitudinal Study of Parents and Children (ALSPAC), Department of Social Medicine, University of Bristol, BS8 2BN, UK 74 Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USA 75 Department of Pediatrics, University of Iowa, Iowa City, IA, USA 76 Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA 77 Department of Oral and Dental Science, University of Bristol, BS1 2LY, UK 78 Department of Medicine, Indiana University School of Medicine, Indiana, USA 79 Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA 80 Genetic and Molecular Epidemiology Laboratory, McMaster University, 1200 Main St. W MDCL Rm. 3206, Hamilton, ON, L8N3Z5, Canada 81 Amgen, 1 Kendall Square, Building 100, Cambridge, MA 02139, USA 83 School of Women's and Infants' Health, The University of Western Australia, Australia 84 Gen Info Ltd; Zagreb, 10000; Croatia 85 Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065, USA 86 Croatian Centre for Global Health; University of Split Medical School; Split, 21000; Croatia 87 Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA 88 UOC Geriatria - Istituto Nazionale Ricovero e Cura per Anziani IRCCS - Rome, Italy 89 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA 90 Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA 91 Division of Community Health Sciences, St. George's, University of London, London, UK 92 Icelandic Cancer Registry, Reykjavik, Iceland 93 Departments of Epidemiology and Public Health and Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 94 Department of Internal Medicine, BH-10 Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland 95 Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany 96 Klinikum Grosshadern, Munich, Germany 97 Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia 98 Division of Cardiology, Brigham and Women's Hospital 99 Faculty of Medicine, University of Iceland, Reykjavik, Iceland 100 Department of Paediatrics, University of Cambridge, Cambridge, UK (literal)
Titolo
  • Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (literal)
Abstract
  • To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10???) and 9q31.2 (P = 2.2 × 10?³³), we identified 30 new menarche loci (all P < 5 × 10??) and found suggestive evidence for a further 10 loci (P < 1.9 × 10??). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing. (literal)
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