New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Articolo in rivista)

Type
Label
  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.520 (literal)
Alternative label
  • Josée Dupuis,1,2; Claudia Langenberg,3; Inga Prokopenko,4,5; Richa Saxena,6,7; Nicole Soranzo,8,9; Anne U Jackson,10; Eleanor Wheeler,11; Nicole L Glazer,12; Nabila Bouatia-Naji,13; Anna L Gloyn,4; Cecilia M Lindgren,4,5; Reedik Mägi,4,5; Andrew P Morris,5; Joshua Randall,5; Toby Johnson,14,15,16; Paul Elliott,17; Denis Rybin,18; Gudmar Thorleifsson,19; Valgerdur Steinthorsdottir,19; Peter Henneman,20; Harald Grallert,21; Abbas Dehghan,22; Jouke Jan Hottenga,23; Christopher S Franklin,24; Pau Navarro,25; Kijoung Song,26; Anuj Goel,5,27; John R B Perry,28; Josephine M Egan,29; Taina Lajunen,30; Niels Grarup,31; Thomas Sparsø,31; Alex Doney,32; Benjamin F Voight,6,7; Heather M Stringham,10; Man Li,33; Stavroula Kanoni,34; Peter Shrader,35; Christine Cavalcanti-Proença,13, Meena Kumari,36; Lu Qi,37; Nicholas J Timpson,38; Christian Gieger,21; Carina Zabena,39; Ghislain Rocheleau,40,41; Erik Ingelsson,42,43; Ping An,44; Jeffrey O'Connell,45; Jian'an Luan,3; Amanda Elliott,6,7; Steven A McCarroll,6,7; Felicity Payne,11; Rosa Maria Roccasecca,11; François Pattou,46; Praveen Sethupathy,47; Kristin Ardlie,48; Yavuz Ariyurek,49; Beverley Balkau,50; Philip Barter,51; John P Beilby,52,53; Yoav Ben-Shlomo,54; Rafn Benediktsson,55,56; Amanda J Bennett,4; Sven Bergmann,14,15; Murielle Bochud,15; Eric Boerwinkle,57; Amélie Bonnefond,13; Lori L Bonnycastle,47; Knut Borch-Johnsen,58,59; Yvonne Böttcher,60; Eric Brunner,36; Suzannah J Bumpstead,8; Guillaume Charpentier,61; Yii-Der Ida Chen,62; Peter Chines,47; Robert Clarke,63; Lachlan J M Coin,17; Matthew N Cooper,64; Marilyn Cornelis,37; Gabe Crawford,6; Laura Crisponi,65; Ian N M Day,38; Eco de Geus,23; Jerome Delplanque,13; Christian Dina,13; Michael R Erdos,47; Annette C Fedson,64,66; Antje Fischer-Rosinsky,67,68; Nita G Forouhi,3; Caroline S Fox,2,69; Rune Frants,70; Maria Grazia Franzosi,71; Pilar Galan,72; Mark O Goodarzi,62; Jürgen Graessler,73; Christopher J Groves,4; Scott Grundy,74; Rhian Gwilliam,8; Ulf Gyllensten,75; Samy Hadjadj,76; Göran Hallmans,77; Naomi Hammond,8; Xijing Han,10; Anna-Liisa Hartikainen,78; Neelam Hassanali,4; Caroline Hayward,25; Simon C Heath,79; Serge Hercberg,80; Christian Herder,81; Andrew A Hicks,82; David R Hillman,66,83; Aroon D Hingorani,36; Albert Hofman,22; Jennie Hui,52,84; Joe Hung,85,86; Bo Isomaa,87,88; Paul R V Johnson,4,89; Torben Jørgensen,90,91; Antti Jula,92; Marika Kaakinen,93; Jaakko Kaprio,94,95,96; Y Antero Kesaniemi,97; Mika Kivimaki,36; Beatrice Knight,98; Seppo Koskinen,99; Peter Kovacs,100; Kirsten Ohm Kyvik,101; G Mark Lathrop,79; Debbie A Lawlor,38; Olivier Le Bacquer,13; Cécile Lecoeur,13; Yun Li,10; Valeriya Lyssenko,102; Robert Mahley,103; Massimo Mangino,9; Alisa K Manning,1; María Teresa Martínez-Larrad,39; Jarred B McAteer,6,104,105; Laura J McCulloch,4; Ruth McPherson,106; Christa Meisinger,21; David Melzer,28; David Meyre,13; Braxton D Mitchell,45; Mario A Morken,47; Sutapa Mukherjee,66,83; Silvia Naitza,65; Narisu Narisu,47; Matthew J Neville,4,107; Ben A Oostra,108; Marco Orrù,65; Ruth Pakyz,45; Colin N A Palmer,109; Giuseppe Paolisso,110; Cristian Pattaro,82; Daniel Pearson,47; John F Peden,5,27; Nancy L. Pedersen,42; Markus Perola,96,111,112; Andreas F H Pfeiffer,67,68; Irene Pichler,82; Ozren Polasek,113; Danielle Posthuma,23,114, Simon C Potter,8; Anneli Pouta,115; Michael A Province,44; Bruce M Psaty,116,117; Wolfgang Rathmann,118; Nigel W Rayner,4,5; Kenneth Rice,119; Samuli Ripatti,96,111; Fernando Rivadeneira,22,120; Michael Roden,81,121; Olov Rolandsson,122; Annelli Sandbaek,123; Manjinder Sandhu,3,124; Serena Sanna,65; Avan Aihie Sayer,125; Paul Scheet,126; Laura J Scott,10; Udo Seedorf,127; Stephen J Sharp,3; Beverley Shields,98; Gunnar Sigurðsson,55,56; Erik J G Sijbrands,22,120; Angela Silveira,128; Laila Simpson,64,66; Andrew Singleton,129; Nicholas L Smith,130,131; Ulla Sovio,17; Amy Swift,47; Holly Syddall,125; Ann-Christine Syvänen,132; Toshiko Tanaka,133,134; Barbara Thorand,21; Jean Tichet,135; Anke Tönjes,60,136; Tiinamaija Tuomi,87,137; André G Uitterlinden,22,120; Ko Willems van Dijk,70,138; Mandy van Hoek,120; Dhiraj Varma,8; Sophie Visvikis-Siest,139; Veronique Vitart,25; Nicole Vogelzangs,140; Gérard Waeber,141; Peter J Wagner,96,111; Andrew Walley,142; G Bragi Walters,19; Kim L Ward,64,66; Hugh Watkins,5,27; Michael N Weedon,28; Sarah H Wild,24; Gonneke Willemsen,23; Jaqueline C M Witteman,22; John W G Yarnell,143; Eleftheria Zeggini,5,8; Diana Zelenika,79; Björn Zethelius,43,144; Guangju Zhai,9; Jing Hua Zhao,3; M Carola Zillikens,120; DIAGRAM Consortium,145; GIANT Consortium,145; Global BPgen Consortium,145; Ingrid B Borecki,44; Ruth J F Loos,3; Pierre Meneton,80; Patrik K E Magnusson,42; David M Nathan,104,105; Gordon H Williams,69,105; Andrew T Hattersley,98; Kaisa Silander,96,111; Veikko Salomaa,146; George Davey Smith,38; Stefan R Bornstein,73; Peter Schwarz,73; Joachim Spranger,67,68; Fredrik Karpe,4,107; Alan R Shuldiner,45; Cyrus Cooper,125; George V Dedoussis,34; Manuel Serrano-Ríos,39; Andrew D Morris,109; Lars Lind,132; Lyle J Palmer,64,66,84; Frank B. Hu,147,148; Paul W Franks,149; Shah Ebrahim,150; Michael Marmot,36; W H Linda Kao,33,151,152; James S Pankow,153; Michael J Sampson,154; Johanna Kuusisto,155; Markku Laakso,155; Torben Hansen,31,156; Oluf Pedersen,31,59,157; Peter Paul Pramstaller,82,158,159; H Erich Wichmann,21,160,161; Thomas Illig,21; Igor Rudan,24,162,163; Alan F Wright,25; Michael Stumvoll,60; Harry Campbell,24; James F Wilson,24; Anders Hamsten,128; on behalf of Procardis consortium Richard N Bergman,164; Thomas A Buchanan,164,165; Francis S Collins,47; Karen L Mohlke,166; Jaakko Tuomilehto,94,167; Timo T Valle,167; David Altshuler,6,7,104,105; Jerome I Rotter,62; David S Siscovick,168; Brenda W J H Penninx,140; Dorret Boomsma,23; Panos Deloukas,8; Timothy D Spector,8,9; Timothy M Frayling,28; Luigi Ferrucci,169; Augustine Kong,19; Unnur Thorsteinsdottir,19,170; Kari Stefansson,19,170; Cornelia M van Duijn,22; Yurii S Aulchenko,22; Antonio Cao,65; Angelo Scuteri,65,171; David Schlessinger,47; Manuela Uda,65; Aimo Ruokonen,172; Marjo-Riitta Jarvelin,17,93,173; Dawn M Waterworth,26; Peter Vollenweider,141; Leena Peltonen,8,48,96,111,112; Vincent Mooser,26; Goncalo R Abecasis,10; Nicholas J Wareham,3; Robert Sladek,40,41; Philippe Froguel,13,142; Richard M Watanabe,164,174; James B Meigs,35,105; Leif Groop,102; Michael Boehnke,10; Mark I McCarthy,4,5,107; Jose C Florez,6,7,104,105; Inês Barroso,11; and for the MAGIC investigators (2010)
    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Josée Dupuis,1,2; Claudia Langenberg,3; Inga Prokopenko,4,5; Richa Saxena,6,7; Nicole Soranzo,8,9; Anne U Jackson,10; Eleanor Wheeler,11; Nicole L Glazer,12; Nabila Bouatia-Naji,13; Anna L Gloyn,4; Cecilia M Lindgren,4,5; Reedik Mägi,4,5; Andrew P Morris,5; Joshua Randall,5; Toby Johnson,14,15,16; Paul Elliott,17; Denis Rybin,18; Gudmar Thorleifsson,19; Valgerdur Steinthorsdottir,19; Peter Henneman,20; Harald Grallert,21; Abbas Dehghan,22; Jouke Jan Hottenga,23; Christopher S Franklin,24; Pau Navarro,25; Kijoung Song,26; Anuj Goel,5,27; John R B Perry,28; Josephine M Egan,29; Taina Lajunen,30; Niels Grarup,31; Thomas Sparsø,31; Alex Doney,32; Benjamin F Voight,6,7; Heather M Stringham,10; Man Li,33; Stavroula Kanoni,34; Peter Shrader,35; Christine Cavalcanti-Proença,13, Meena Kumari,36; Lu Qi,37; Nicholas J Timpson,38; Christian Gieger,21; Carina Zabena,39; Ghislain Rocheleau,40,41; Erik Ingelsson,42,43; Ping An,44; Jeffrey O'Connell,45; Jian'an Luan,3; Amanda Elliott,6,7; Steven A McCarroll,6,7; Felicity Payne,11; Rosa Maria Roccasecca,11; François Pattou,46; Praveen Sethupathy,47; Kristin Ardlie,48; Yavuz Ariyurek,49; Beverley Balkau,50; Philip Barter,51; John P Beilby,52,53; Yoav Ben-Shlomo,54; Rafn Benediktsson,55,56; Amanda J Bennett,4; Sven Bergmann,14,15; Murielle Bochud,15; Eric Boerwinkle,57; Amélie Bonnefond,13; Lori L Bonnycastle,47; Knut Borch-Johnsen,58,59; Yvonne Böttcher,60; Eric Brunner,36; Suzannah J Bumpstead,8; Guillaume Charpentier,61; Yii-Der Ida Chen,62; Peter Chines,47; Robert Clarke,63; Lachlan J M Coin,17; Matthew N Cooper,64; Marilyn Cornelis,37; Gabe Crawford,6; Laura Crisponi,65; Ian N M Day,38; Eco de Geus,23; Jerome Delplanque,13; Christian Dina,13; Michael R Erdos,47; Annette C Fedson,64,66; Antje Fischer-Rosinsky,67,68; Nita G Forouhi,3; Caroline S Fox,2,69; Rune Frants,70; Maria Grazia Franzosi,71; Pilar Galan,72; Mark O Goodarzi,62; Jürgen Graessler,73; Christopher J Groves,4; Scott Grundy,74; Rhian Gwilliam,8; Ulf Gyllensten,75; Samy Hadjadj,76; Göran Hallmans,77; Naomi Hammond,8; Xijing Han,10; Anna-Liisa Hartikainen,78; Neelam Hassanali,4; Caroline Hayward,25; Simon C Heath,79; Serge Hercberg,80; Christian Herder,81; Andrew A Hicks,82; David R Hillman,66,83; Aroon D Hingorani,36; Albert Hofman,22; Jennie Hui,52,84; Joe Hung,85,86; Bo Isomaa,87,88; Paul R V Johnson,4,89; Torben Jørgensen,90,91; Antti Jula,92; Marika Kaakinen,93; Jaakko Kaprio,94,95,96; Y Antero Kesaniemi,97; Mika Kivimaki,36; Beatrice Knight,98; Seppo Koskinen,99; Peter Kovacs,100; Kirsten Ohm Kyvik,101; G Mark Lathrop,79; Debbie A Lawlor,38; Olivier Le Bacquer,13; Cécile Lecoeur,13; Yun Li,10; Valeriya Lyssenko,102; Robert Mahley,103; Massimo Mangino,9; Alisa K Manning,1; María Teresa Martínez-Larrad,39; Jarred B McAteer,6,104,105; Laura J McCulloch,4; Ruth McPherson,106; Christa Meisinger,21; David Melzer,28; David Meyre,13; Braxton D Mitchell,45; Mario A Morken,47; Sutapa Mukherjee,66,83; Silvia Naitza,65; Narisu Narisu,47; Matthew J Neville,4,107; Ben A Oostra,108; Marco Orrù,65; Ruth Pakyz,45; Colin N A Palmer,109; Giuseppe Paolisso,110; Cristian Pattaro,82; Daniel Pearson,47; John F Peden,5,27; Nancy L. Pedersen,42; Markus Perola,96,111,112; Andreas F H Pfeiffer,67,68; Irene Pichler,82; Ozren Polasek,113; Danielle Posthuma,23,114, Simon C Potter,8; Anneli Pouta,115; Michael A Province,44; Bruce M Psaty,116,117; Wolfgang Rathmann,118; Nigel W Rayner,4,5; Kenneth Rice,119; Samuli Ripatti,96,111; Fernando Rivadeneira,22,120; Michael Roden,81,121; Olov Rolandsson,122; Annelli Sandbaek,123; Manjinder Sandhu,3,124; Serena Sanna,65; Avan Aihie Sayer,125; Paul Scheet,126; Laura J Scott,10; Udo Seedorf,127; Stephen J Sharp,3; Beverley Shields,98; Gunnar Sigurðsson,55,56; Erik J G Sijbrands,22,120; Angela Silveira,128; Laila Simpson,64,66; Andrew Singleton,129; Nicholas L Smith,130,131; Ulla Sovio,17; Amy Swift,47; Holly Syddall,125; Ann-Christine Syvänen,132; Toshiko Tanaka,133,134; Barbara Thorand,21; Jean Tichet,135; Anke Tönjes,60,136; Tiinamaija Tuomi,87,137; André G Uitterlinden,22,120; Ko Willems van Dijk,70,138; Mandy van Hoek,120; Dhiraj Varma,8; Sophie Visvikis-Siest,139; Veronique Vitart,25; Nicole Vogelzangs,140; Gérard Waeber,141; Peter J Wagner,96,111; Andrew Walley,142; G Bragi Walters,19; Kim L Ward,64,66; Hugh Watkins,5,27; Michael N Weedon,28; Sarah H Wild,24; Gonneke Willemsen,23; Jaqueline C M Witteman,22; John W G Yarnell,143; Eleftheria Zeggini,5,8; Diana Zelenika,79; Björn Zethelius,43,144; Guangju Zhai,9; Jing Hua Zhao,3; M Carola Zillikens,120; DIAGRAM Consortium,145; GIANT Consortium,145; Global BPgen Consortium,145; Ingrid B Borecki,44; Ruth J F Loos,3; Pierre Meneton,80; Patrik K E Magnusson,42; David M Nathan,104,105; Gordon H Williams,69,105; Andrew T Hattersley,98; Kaisa Silander,96,111; Veikko Salomaa,146; George Davey Smith,38; Stefan R Bornstein,73; Peter Schwarz,73; Joachim Spranger,67,68; Fredrik Karpe,4,107; Alan R Shuldiner,45; Cyrus Cooper,125; George V Dedoussis,34; Manuel Serrano-Ríos,39; Andrew D Morris,109; Lars Lind,132; Lyle J Palmer,64,66,84; Frank B. Hu,147,148; Paul W Franks,149; Shah Ebrahim,150; Michael Marmot,36; W H Linda Kao,33,151,152; James S Pankow,153; Michael J Sampson,154; Johanna Kuusisto,155; Markku Laakso,155; Torben Hansen,31,156; Oluf Pedersen,31,59,157; Peter Paul Pramstaller,82,158,159; H Erich Wichmann,21,160,161; Thomas Illig,21; Igor Rudan,24,162,163; Alan F Wright,25; Michael Stumvoll,60; Harry Campbell,24; James F Wilson,24; Anders Hamsten,128; on behalf of Procardis consortium Richard N Bergman,164; Thomas A Buchanan,164,165; Francis S Collins,47; Karen L Mohlke,166; Jaakko Tuomilehto,94,167; Timo T Valle,167; David Altshuler,6,7,104,105; Jerome I Rotter,62; David S Siscovick,168; Brenda W J H Penninx,140; Dorret Boomsma,23; Panos Deloukas,8; Timothy D Spector,8,9; Timothy M Frayling,28; Luigi Ferrucci,169; Augustine Kong,19; Unnur Thorsteinsdottir,19,170; Kari Stefansson,19,170; Cornelia M van Duijn,22; Yurii S Aulchenko,22; Antonio Cao,65; Angelo Scuteri,65,171; David Schlessinger,47; Manuela Uda,65; Aimo Ruokonen,172; Marjo-Riitta Jarvelin,17,93,173; Dawn M Waterworth,26; Peter Vollenweider,141; Leena Peltonen,8,48,96,111,112; Vincent Mooser,26; Goncalo R Abecasis,10; Nicholas J Wareham,3; Robert Sladek,40,41; Philippe Froguel,13,142; Richard M Watanabe,164,174; James B Meigs,35,105; Leif Groop,102; Michael Boehnke,10; Mark I McCarthy,4,5,107; Jose C Florez,6,7,104,105; Inês Barroso,11; and for the MAGIC investigators (literal)
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  • 105 (literal)
Pagina fine
  • 116 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 42 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA 2National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts 01702, USA 3MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK 4Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK 5Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK 6Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA 7Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 8Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK 9Twin Research & Genetic Epidemiology Department, King's College London, St Thomas' Hospital Campus, Lambeth Palace Rd, London SE1 7EH, UK 10Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA 11Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK 12Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, USA 13CNRS-UMR8090, Pasteur Institute, Lille 2-Droit et Santé University, F-59000 Lille, France 14Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland 15University Institute of Social and Preventative Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, 1005 Lausanne, Switzerland 16Swiss Institute of Bioinformatics, Switzerland 17Department of Epidemiology and Public Health, Imperial College of London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK 18Boston University Data Coordinating Center, Boston, Massachusetts 02118, USA 19deCODE Genetics, 101 Reykjavik, Iceland 20Department of Human Genetics, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands 21Institute of Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany 22Department of Epidemiology, Erasmus MC Rotterdam, 3000 CA, The Netherlands 23Department of Biological Psychology, VU, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands 24Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK 25MRC Human Genetics Unit, IGMM, Edinburgh EH4 2XU, UK 26Division of Genetics, R&D, Glaxo SmithKline, King of Prussia, Pennsylvania 19406, USA 27Department of Cardiovascular Medicine, University of Oxford, Oxford OX3 9DU, UK 28Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter EX1 2LU, UK 29Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland 21250, USA 30Unit for Child and Adolescent Health and Welfare, National Institute for Health and Welfare, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland 31Hagedorn Research Institute, 2820 Gentofte, Denmark 32Department of Medicine & Therapeutics, Level 7, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK 33Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA 34Department of Nutrition - Dietetics, Harokopio University, 17671 Athens, Greece 35General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA 36Department of Epidemiology and Public Health, University College London, UK 37Depts. of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA 38MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol BS8 2PR, UK 39Fundación para la Investigación Biomédica del Hospital Clínico San Carlos, Madrid, Spain 40Departments of Medicine and Human Genetics, McGill University, Montreal, Canada 41Genome Quebec Innovation Centre, Montreal H3A 1A4, Canada 42Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden 43Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden 44Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA 45Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA 46INSERM U859, Universite de Lille-Nord de France, F-59000 Lille, France 47Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA 48The Broad Institute, Cambridge, Massachusetts 02141, USA 49Leiden Genome Technology Center, Leiden University Medical Center, 2300 RC Leiden, The Netherlands 50INSERM U780-IFR69, Paris Sud University, F-94807 Villejuif, France 51The Heart Research Institute, Sydney, New South Wales, Australia 52PathWest Laboratory of Western Australia, Department of Molecular Genetics, J Block, QEII Medical Centre, NEDLANDS WA 6009, Australia 53School of Surgery and Pathology, University of Western Australia, Nedlands WA 6009, Australia 54Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK 55Landspitali University Hospital, 101 Reykjavik, Iceland 56Icelandic Heart Association, 201 Kopavogur, Iceland 57The Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA 58Steno Diabetes Center, DK-2820 Gentofte, Copenhagen, Denmark 59Faculty of Health Science, University of Aarhus, Aarhus DK-8000, Denmark 60Department of Medicine, University of Leipzig, Liebigstr. 18, 04103 Leipzig, Germany 61Endocrinology-Diabetology Unit, Corbeil-Essonnes Hospital, Essonnes, F-91108 France 62Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA 63Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF, UK 64Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Australia 65Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy 66Western Australian Sleep Disorders Research Institute, Queen Elizabeth Medical Centre II, Perth, Australia 67Department of Endocrinology, Diabetes and Nutrition, Charite-Universitaetsmedizin Berlin, Berlin, Germany 68Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany 69Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA 70Department of Human Genetics, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands 71Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy 72U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Université Paris 13, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France 73Department of Medicine III, Division Prevention and Care of Diabetes, University of Dresden, 01307 Dresden 74Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, USA 75Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, S-751 85 Uppsala, Sweden 76CHU de Poitiers, Endocrinologie Diabetologie, CIC INSERM 0802, INSERM U927, Université de Poitiers, UFR, Médecine Pharmacie, Poitiers, France 77Department of Public Health & Clinical Medicine, Section for Nutritional Research, Umeå University, Umeå, Sweden 78Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Box 5000, Fin-90014 University of Oulu, Finland 79Centre National de Génotypage/IG/CEA, 2 rue Gaston Crémieux CP 5721, 91057 Evry Cedex, France 80U872 Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Paris Descartes, 15 rue de l'Ecole de Médecine, 75270 Paris Cedex, France 81Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany 82Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy, Affiliated Institute of the University Lübeck, Germany 83Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Australia 84Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Australia 85Heart Institute of Western Australia, Sir Charles Gairdner Hospital, Nedlands WA 6009, Australia 86School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia 87Folkhalsan Research Centre, Helsinki, Finland 88Malmska Municipal Health Care Center and Hospital, Jakobstad, Finland 89Nuffield Department of Surgery, University of Oxford, Oxford OX3 9DU, UK 90Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark 91Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark 92National Institute for Health and Welfare, Unit of Population Studies, Turku, Finland 93Institute of Health Sciences and Biocenter Oulu, Box 5000, Fin-90014 University of Oulu, Finland 94Department of Public Health, Faculty of Medicine, P.O. Box 41 (Mannerheimintie 172), University of Helsinki, 00014 Helsinki, Finland 95National Institute for Health and Welfare, Unit for Child and Adolescent Mental Health, Helsinki, Finland 96Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland 97Department of Internal Medicine and Biocenter Oulu, Oulu, Finland 98Diabetes Genetics, Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX2 5DW, UK 99National Institute for Health and Welfare, Unit of Living Conditions, Health and Wellbeing, Helsinki, Finland 100Interdisciplinary Centre for Clinical Research, University of Leipzig, Inselstr. 22, 04103 Leipzig, Germany 101The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9B, 5000 Odense, Denmark 102Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden 103Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA 104Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, Massachusetts 02114, USA 105Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA 106Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada 107Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ, UK 108Department of Clinical Genetics, Erasmus MC Rotterdam, 3000 CA, The Netherlands 109Biomedical Research Institute, University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK 110Department of Geriatric Medicine and Metabolic Disease, Second University of Naples, Naples, Italy. 111National Institute for Health and Welfare, Unit of Public Health Genomics, Helsinki, Finland 112Department of Medical Genetics, University of Helsinki, Helsinki, Finland 113Department of Medical Statistics, Epidemiology and Medical Informatics, Andrija Stampar School of Public Health, Medical School, University of Zagreb, Rockefellerova 4, 10000 Zagreb, Croatia 114Department of Clinical Genetics, VUMC, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands 115Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland 116Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, USA 117Group Health Center for Health Studies, Seattle, Washington, USA 118Institute of Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Düsseldorf, Germany 119Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA 120Department of Internal Medicine, Erasmus MC Rotterdam, 3000 CA, The Netherlands 121Department of Medicine/Metabolic Diseases, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany 122Department of Public Health & Clinical Medicine, Section for Family Medicine, Umeå University Hospital, Umeå, Sweden 123School of Public Health, Department of General Practice, University of Aarhus, Aarhus DK-8000, Denmark 124Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK 125MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK 126Department of Epidemiology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA 127Leibniz-Institut für Arterioskleroseforschung an der Universität Münster,Münster, Germany 128Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden 129Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA 130Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA 131Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, Washington, USA 132Department of Medical Sciences, Uppsala University, Uppsala, Sweden 133Medstar Research Institute, Baltimore, Maryland 21250, USA 134Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA 135Institut interrégional pour la santé (IRSA), F-37521 La Riche, France 136Coordination Centre for Clinical Trials, University of Leipzig, Härtelstr. 16-18, 04103 Leipzig, Germany 137Department of Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland 138Department of Internal Medicine, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands 139Research Unit, Cardiovascular Genetics, Nancy University Henri Poincaré, Nancy, France 140EMGO Institute/Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands 141Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland 142Genomic Medicine, Imperial College London, Hammersmith Hospital, W12 0NN, London, UK 143Epidemiology & Public Health, Queen's University Belfast, Belfast BT12 6BJ, UK 144Medical Products Agency, Uppsala, Sweden 146National Institute for Health and Welfare, Unit of Chronic Disease Epidemiology and Prevention, Helsinki, Finland 147Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA 148Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA 149Genetic Epidemiology & Clinical Research Group, Department of Public Health & Clinical Medicine, Section for Medicine, Umeå University Hospital, Umeå, Sweden 150London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK 151Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA 152The Welch Center for Prevention, Epidemiology, and Clinical Research, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA 153Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA 154Department of Endocrinology and Diabetes, Norfolk and Norwich University Hospital NHS Trust, Norwich, NR1 7UY, UK 155Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio 70210, Finland 156Faculty of Health Science, University of Southern Denmark, Odense, Denmark 157Institute of Biomedical Science, Faculty of Health Science, University of Copenhagen, Denmark 158Department of Neurology, General Central Hospital, 39100 Bolzano, Italy 159Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany 160Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany 161Klinikum Grosshadern, Munich, Germany 162School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia 163Gen-Info Ltd, Ruzmarinka 17, 10000 Zagreb, Croatia 164Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA 165Department of Medicine, Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA 166Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA 167National Institute for Health and Welfare, Unit of Diabetes Prevention, Helsinki, Finland 168Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, USA 169Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA 170Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland 171Lab of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, Maryland, USA 172Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Box 5000, Fin-90014 University of Oulu, Finland 173National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, Fin-90101 Oulu, Finland 174Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033, USA (literal)
Titolo
  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (literal)
Abstract
  • Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes (literal)
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