Variants in MTNR1B influence fasting glucose levels (Articolo in rivista)

Type
Label
  • Variants in MTNR1B influence fasting glucose levels (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.290 (literal)
Alternative label
  • Inga Prokopenko;1,2* Claudia Langenberg;3* Jose C. Florez;4,5,6* Richa Saxena;4,7* Nicole Soranzo;8,9* Gudmar Thorleifsson;10 Ruth J.F. Loos;3 Alisa K. Manning;11 Anne U. Jackson;12 Yurii Aulchenko;13 Simon C. Potter;8 Michael R. Erdos;14 Serena Sanna;15 Jouke-Jan Hottenga;16 Eleanor Wheeler;8 Marika Kaakinen;17 Valeriya Lyssenko;18 Wei-Min Chen;19,20 Kourosh Ahmadi;9 Jacques S. Beckmann;21,22 Richard N. Bergman;23 Murielle Bochud;24 Lori L. Bonnycastle;14 Thomas A. Buchanan;25 Antonio Cao;15 Alessandra Cervino;9 Lachlan Coin;26 Francis S. Collins;14 Laura Crisponi;15 Eco JC de Geus;16 Abbas Dehghan;13 Panos Deloukas;8 Alex S F Doney;27 Paul Elliott;26 Nelson Freimer;28 Vesela Gateva;12 Christian Herder;29 Albert Hofman;13 Thomas E. Hughes;30 Sarah Hunt;8 Thomas Illig;31 Michael Inouye;8 Bo Isomaa;32 Toby Johnson;21,24,33 Augustine Kong;10 Maria Krestyaninova;34 Johanna Kuusisto;35 Markku Laakso;35 Noha Lim;36 Ulf Lindblad;37,38 Cecilia M. Lindgren;2 Owen T. McCann;8 Karen L. Mohlke;39 Andrew D Morris;27 Silvia Naitza;15 Marco Orrù;15 Colin N A Palmer;40 Anneli Pouta;41,42 Joshua Randall;2 Wolfgang Rathmann;43 Jouko Saramies;44 Paul Scheet;12 Laura J. Scott;12 Angelo Scuteri;14,45 Stephen Sharp;3 Eric Sijbrands;46 Jan H. Smit;16 Kijoung Song;36 Valgerdur Steinthorsdottir;10 Heather M. Stringham;12 Tiinamaija Tuomi;47 Jaakko Tuomilehto;48,49 André G. Uitterlinden;46 Benjamin F. Voight;4,7 Dawn Waterworth;36 H.-Erich Wichmann;31,50 Gonneke Willemsen;16 Jacqueline CM Witteman;13 Xin Yuan;36 Jing Hua Zhao;3 Eleftheria Zeggini;2 David Schlessinger;51 Manjinder Sandhu;3,52 Dorret I Boomsma;16 Manuela Uda;15 Tim D. Spector;9 Brenda WJH Penninx;53,54,55 David Altshuler;4,7 Peter Vollenweider;56 Marjo Riitta Jarvelin;17,26,42 Edward Lakatta;51 Gerard Waeber;56 Caroline S. Fox;57,58 Leena Peltonen;8,59,60 Leif C. Groop;18 Vincent Mooser;36 L. Adrienne Cupples;11 Unnur Thorsteinsdottir;10,61 Michael Boehnke;12 Inês Barroso;8 Cornelia Van Duijn;13 Josée Dupuis;11 Richard M. Watanabe;23,62 Kari Stefansson;10,16 Mark I. McCarthy;1,2 Nicholas J. Wareham;3 James B. Meigs;5,63 and Goncalo R. Abecasis12+; for the MAGIC investigators (2009)
    Variants in MTNR1B influence fasting glucose levels
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Inga Prokopenko;1,2* Claudia Langenberg;3* Jose C. Florez;4,5,6* Richa Saxena;4,7* Nicole Soranzo;8,9* Gudmar Thorleifsson;10 Ruth J.F. Loos;3 Alisa K. Manning;11 Anne U. Jackson;12 Yurii Aulchenko;13 Simon C. Potter;8 Michael R. Erdos;14 Serena Sanna;15 Jouke-Jan Hottenga;16 Eleanor Wheeler;8 Marika Kaakinen;17 Valeriya Lyssenko;18 Wei-Min Chen;19,20 Kourosh Ahmadi;9 Jacques S. Beckmann;21,22 Richard N. Bergman;23 Murielle Bochud;24 Lori L. Bonnycastle;14 Thomas A. Buchanan;25 Antonio Cao;15 Alessandra Cervino;9 Lachlan Coin;26 Francis S. Collins;14 Laura Crisponi;15 Eco JC de Geus;16 Abbas Dehghan;13 Panos Deloukas;8 Alex S F Doney;27 Paul Elliott;26 Nelson Freimer;28 Vesela Gateva;12 Christian Herder;29 Albert Hofman;13 Thomas E. Hughes;30 Sarah Hunt;8 Thomas Illig;31 Michael Inouye;8 Bo Isomaa;32 Toby Johnson;21,24,33 Augustine Kong;10 Maria Krestyaninova;34 Johanna Kuusisto;35 Markku Laakso;35 Noha Lim;36 Ulf Lindblad;37,38 Cecilia M. Lindgren;2 Owen T. McCann;8 Karen L. Mohlke;39 Andrew D Morris;27 Silvia Naitza;15 Marco Orrù;15 Colin N A Palmer;40 Anneli Pouta;41,42 Joshua Randall;2 Wolfgang Rathmann;43 Jouko Saramies;44 Paul Scheet;12 Laura J. Scott;12 Angelo Scuteri;14,45 Stephen Sharp;3 Eric Sijbrands;46 Jan H. Smit;16 Kijoung Song;36 Valgerdur Steinthorsdottir;10 Heather M. Stringham;12 Tiinamaija Tuomi;47 Jaakko Tuomilehto;48,49 André G. Uitterlinden;46 Benjamin F. Voight;4,7 Dawn Waterworth;36 H.-Erich Wichmann;31,50 Gonneke Willemsen;16 Jacqueline CM Witteman;13 Xin Yuan;36 Jing Hua Zhao;3 Eleftheria Zeggini;2 David Schlessinger;51 Manjinder Sandhu;3,52 Dorret I Boomsma;16 Manuela Uda;15 Tim D. Spector;9 Brenda WJH Penninx;53,54,55 David Altshuler;4,7 Peter Vollenweider;56 Marjo Riitta Jarvelin;17,26,42 Edward Lakatta;51 Gerard Waeber;56 Caroline S. Fox;57,58 Leena Peltonen;8,59,60 Leif C. Groop;18 Vincent Mooser;36 L. Adrienne Cupples;11 Unnur Thorsteinsdottir;10,61 Michael Boehnke;12 Inês Barroso;8 Cornelia Van Duijn;13 Josée Dupuis;11 Richard M. Watanabe;23,62 Kari Stefansson;10,16 Mark I. McCarthy;1,2 Nicholas J. Wareham;3 James B. Meigs;5,63 and Goncalo R. Abecasis12+; for the MAGIC investigators (literal)
Pagina inizio
  • 77 (literal)
Pagina fine
  • 81 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 41 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ. 2Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK. 3MRC Epidemiology Unit, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. 4Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA. 5Department of Medicine, Harvard Medical School, Boston, MA, USA. 6Center for Human Genetic Research and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. 7Center for Human Genetic Research, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. 8Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, Cambridge, UK. 9Twin Research and Genetic Epidemiology Department, King's College London, St Thomas' Hospital Campus, Lambeth Palace Rd, London SE1 7EH, UK. 10deCODE genetics, 101 Reykjavík, Iceland. 11Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA 12Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. 13Department of Epidemiology, Erasmus MC Rotterdam, Postbus 2040, 3000 CA Rotterdam, the Netherlands. 14Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA. 15Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy. 16Department of Biological Psychology, VU University Amsterdam, van der Boechorstraat 1, 1081 BT Amsterdam, the Netherlands. 17Institute of Health Sciences and Biocenter Oulu, P.O. Box 5000, 90014 University of Oulu, Finland. 18Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden 19Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908-0717, USA. 20Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908-0717, USA. 21Department of Medical Genetics, University of Lausanne, 1005, Switzerland. 22Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, 1011, Switzerland. 23Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. 24University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, 1011 Switzerland. 25Department of Medicine, Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. 26Department of Epidemiology and Public Health, Imperial College of London, Norfolk Place, London W2 1PG, UK. 27Diabetes Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK. 28Center for Neurobehavioral Genetics, University of California, 695 Charles E. Young Drive South, Los Angeles, CA 90095-1761, USA. 29Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University, Düsseldorf, Germany. 30Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research. 31Helmholtz Zentrum Muenchen, National Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany. 32Malmska Municipal Health Center and Hospital, Jakobstad, Finland. 33Swiss Institute of Bioinformatics, Switzerland. 34EMBL-EBI, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK. 35Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland. 36Medical Genetics/Clinical Pharmacology and Discovery Medicine, GSK, King of Prussia, Pennsylvania 19406, USA. 37Skaraborg Institute, Skovde, Sweden. 38Department of Clinical Sciences, Community Medicine, Lund University, University Hospital Malmo, Malmo, Sweden. 39Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. 40Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, UK. 41Department of Obstetrics and Gynaecology, Oulu University Hospital, Finland. 42Department of Child and Adolescent Health, National Public Health Institute (KTL), Aapistie 1, P.O. Box 310, FIN-90101 Oulu, Finland. 43Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University, Düsseldorf, Germany. 44Savitaipale Health Center, 54800 Savitaipale, Finland. 45Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy. 46Department of Internal Medicine, Erasmus MC, Postbus 2040, 3000 CA Rotterdam, The Netherlands. 47Department of Medicine, Helsinki University Hospital, University of Helsinki, Finland. 48Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, 00300 Finland. 49South Ostrobothnia Central Hospital, Senäjoki, 60220 Finland. 50IBE, Chair of Epidemiology, University of Munich, Germany. 51Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA. 52Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK. 53Department of Psychiatry, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands. 54Department of Psychiatry, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, the Netherlands. 55Department of Psychiatry, EMGO Institute, Institute of Neuroscience, VU University Medical Center, A.J. Ernstraat 887, 1081 HL Amsterdam, the Netherlands. 56Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, 1011, Switzerland. 57Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. 58The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA. 59Institute of Molecular Medicine, Biomedicum, 00290 Helsinki, Finland. 60Massachusetts Institute of Technology, The Broad Institute, Cambridge, MA 02141-2023, USA. 61Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland. 62Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. 63General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts. (literal)
Titolo
  • Variants in MTNR1B influence fasting glucose levels (literal)
Abstract
  • To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06–0.08) mmol/l in fasting glucose levels (P =3.2 x 10-50) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10-15). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05–1.12), per G allele P =3.3 x 10-7) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10-57) and GCK (rs4607517, P = 1.0 x10-25) loci. (literal)
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