http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37279
Common variants at 30 loci contribute to polygenic dyslipidemia (Articolo in rivista)
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- Common variants at 30 loci contribute to polygenic dyslipidemia (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Kathiresan, S. et al (literal)
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- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- ISI Web of Science (WOS) (literal)
- Titolo
- Common variants at 30 loci contribute to polygenic dyslipidemia (literal)
- Abstract
- Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors
for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840
individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations
(each with P < 5 x 10-8), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P<10-15 for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia (literal)
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