Genomewide association study of PR interval (Articolo in rivista)

Type
Label
  • Genomewide association study of PR interval (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.517 (literal)
Alternative label
  • Arne Pfeufer1,2,48; Charlotte van Noord3-5,48; Kristin D Marciante6,48; Dan E Arking7,48; Martin G Larson8,9,48; Albert Vernon Smith10,48; Kirill V Tarasov11,12,48; Martina Müller13,14; Nona Sotoodehnia15; Moritz F Sinner14; Germaine C Verwoert3,16; Man Li17; W H Linda Kao17; Anna Köttgen17; Josef Coresh17; Joshua C Bis6; Bruce M Psaty6,18-20; Kenneth Rice21; Jerome I Rotter22; Fernando Rivadeneira3,16; Albert Hofman3; Jan A Kors23; Bruno H C Stricker3,16,24; André G Uitterlinden3,16; Cornelia M van Duijn3; Britt M Beckmann14; Wiebke Sauter13; Christian Gieger13; Steven A Lubitz25,26; Christopher Newton-Cheh26-28; Thomas J Wang9,26,28; Jared W Magnani29; Renate B Schnabel9,30; Mina K Chung31; John Barnard31; Jonathan D Smith31; David R Van Wagoner31; Ramachandran S Vasan9,29; Thor Aspelund10,32; Gudny Eiriksdottir10; Tamara B Harris33; Lenore J Launer33; Samer S Najjar11; Edward Lakatta11; David Schlessinger12; Manuela Uda34; Gonçalo R Abecasis35; Bertram Müller-Myhsok36; Georg B Ehret7; Eric Boerwinkle37; Aravinda Chakravarti7,38; Elsayed Z Soliman39; Kathryn L Lunetta40; Siegfried Perz41; H-Erich Wichmann13,42,43; Thomas Meitinger1,2; Daniel Levy9,44; Vilmundur Gudnason10,32,48; Patrick T Ellinor26-28,48; Serena Sanna34,48; Stefan Kääb14,48; Jacqueline C M Witteman3,5,48; Alvaro Alonso45,48; Emelia J Benjamin9,46-48; Susan R Heckbert18,20,48. (2010)
    Genomewide association study of PR interval
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Arne Pfeufer1,2,48; Charlotte van Noord3-5,48; Kristin D Marciante6,48; Dan E Arking7,48; Martin G Larson8,9,48; Albert Vernon Smith10,48; Kirill V Tarasov11,12,48; Martina Müller13,14; Nona Sotoodehnia15; Moritz F Sinner14; Germaine C Verwoert3,16; Man Li17; W H Linda Kao17; Anna Köttgen17; Josef Coresh17; Joshua C Bis6; Bruce M Psaty6,18-20; Kenneth Rice21; Jerome I Rotter22; Fernando Rivadeneira3,16; Albert Hofman3; Jan A Kors23; Bruno H C Stricker3,16,24; André G Uitterlinden3,16; Cornelia M van Duijn3; Britt M Beckmann14; Wiebke Sauter13; Christian Gieger13; Steven A Lubitz25,26; Christopher Newton-Cheh26-28; Thomas J Wang9,26,28; Jared W Magnani29; Renate B Schnabel9,30; Mina K Chung31; John Barnard31; Jonathan D Smith31; David R Van Wagoner31; Ramachandran S Vasan9,29; Thor Aspelund10,32; Gudny Eiriksdottir10; Tamara B Harris33; Lenore J Launer33; Samer S Najjar11; Edward Lakatta11; David Schlessinger12; Manuela Uda34; Gonçalo R Abecasis35; Bertram Müller-Myhsok36; Georg B Ehret7; Eric Boerwinkle37; Aravinda Chakravarti7,38; Elsayed Z Soliman39; Kathryn L Lunetta40; Siegfried Perz41; H-Erich Wichmann13,42,43; Thomas Meitinger1,2; Daniel Levy9,44; Vilmundur Gudnason10,32,48; Patrick T Ellinor26-28,48; Serena Sanna34,48; Stefan Kääb14,48; Jacqueline C M Witteman3,5,48; Alvaro Alonso45,48; Emelia J Benjamin9,46-48; Susan R Heckbert18,20,48. (literal)
Pagina inizio
  • 153 (literal)
Pagina fine
  • 159 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 42 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, Germany 2 Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany 3 Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands 4 Dutch Medicines Evaluation Board, the Hague, the Netherlands 5 Netherlands Consortium on Healthy Aging (NCHA) 6 Department of Medicine, University of Washington. Seattle WA, USA 7 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA 8 Department of Mathematics and Statistics, Boston University, Boston, MA, USA 9 National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA 10 Icelandic Heart Association, Heart Preventive Clinic and Research Institute, Kopavogur, Iceland 11 Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, MD, USA 12 Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA 13 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany 14 Department of Medicine I, Klinikum Grosshadern, Munich, Germany 15 Division of Cardiology, Department of Medicine, University of Washington, Seattle WA, USA 16 Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands 17 Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA 18 Department of Epidemiology, University of Washington, Seattle WA 19 Department of Health Services, University of Washington, Seattle WA 20 Group Health Research Institute, Seattle, WA 21 Department of Biostatistics, University of Washington, Seattle, WA, USA 22 Medical Genetics Institute, Department of Common Diseases Genetics Program, Cedars-Sinai Med Center, West Hollywood, CA, USA 23 Department of Medical Informatics, Erasmus Medical Center, Rotterdam, the Netherlands 24 Inspectorate for Health Care, The Hague, the Netherlands 25 Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA 26 Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA 27 Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA 28 Cardiology Division, Massachusetts General Hospital, Boston, MA, USA 29 Boston University School of Medicine, Boston, MA, USA 30 Gutenberg Heart Study, Medical Clinic II (Cardiology), Johannes Gutenberg-University, Mainz, Germany 31 Heart & Vascular and Lerner Research Institutes, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA 32 University of Iceland, Reykjavik, Iceland 33 Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Baltimore, MD, USA 34 Istituto di Neurogenetica e Neurofarmacologia, CNR, Monserrato, 09042 Cagliari, Italy 35 Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA 36 Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany 37 Human Genetics Center and Institute for Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA 38 Department of Medicine, Johns Hopkins University, Baltimore, MD, USA 39 Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University Medical Center, Winston-Salem, NC, USA 40 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA 41 Institute of Biological and Medical Imaging, Helmholtz Center Munich, Germany 42 Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany 43 Klinikum Grosshadern, Munich, Germany 44 Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MD, USA 45 Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA 46 Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA 47 Cardiology and Preventive Medicine Division, Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA (literal)
Titolo
  • Genomewide association study of PR interval (literal)
Abstract
  • The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 x10-8. At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N= 5,741 cases, P < 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation. (literal)
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