The Role of Metals in beta-Amyloid Peptide Aggregation: X-Ray Spectroscopy and Numerical Simulations (Articolo in rivista)

Type
Label
  • The Role of Metals in beta-Amyloid Peptide Aggregation: X-Ray Spectroscopy and Numerical Simulations (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Morante, S (2008)
    The Role of Metals in beta-Amyloid Peptide Aggregation: X-Ray Spectroscopy and Numerical Simulations
    in Current Alzheimer research (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Morante, S (literal)
Pagina inizio
  • 508 (literal)
Pagina fine
  • 524 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • \"[Morante, S.] Univ Roma Tor Vergata, Dipartimento Fis, Ist Nazl Fis Nucl, Sez Roma Tor Vergata, I-00133 Rome, Italy; [Morante, S.] Univ Roma La Sapienza, Dipartimento Fis, CRS SOFT, I-00185 Rome, Italy (literal)
Titolo
  • The Role of Metals in beta-Amyloid Peptide Aggregation: X-Ray Spectroscopy and Numerical Simulations (literal)
Abstract
  • The aim of this review is to show how the challenging problem of understanding the physico-chemical basis of protein misfolding and aggregation which are at the origin of plaque formation in amyloid pathologies can be successfully investigated with a combination of modern spectroscopic techniques and advanced first principle numerical simulations. Within the vast group of diseases (more than 20) characterized by extra-cellular deposition of fibrillar material and generically called Amyloidosis, we shall focus on the Alzheimer's disease, a progressive and devastating neurodegenerative pathology affecting an important fraction of the world aged population. Well identified peptides (the so called A beta peptides) undergo a misfolding process during the development of the disease. An important, but not yet fully elucidated, r le appears to be played in these processes by transition metals (mainly copper and zinc) that have been observed to be present in large amounts in patient's neurological plaques. Starting from this observation, a number of interesting results concerning the structural properties of the relevant metalpeptide binding site, emerging from the interplay between X-ray Absorption Spectroscopy experiments, and ab initio molecular dynamics simulations of the Car-Parrinello type will be reported and discussed. (literal)
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