Common variants at ten loci modulate the QT interval duration in the QTSCD Study (Articolo in rivista)

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  • Common variants at ten loci modulate the QT interval duration in the QTSCD Study (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.362 (literal)
Alternative label
  • Arne Pfeufer1,2,25; Serena Sanna3,25; Dan E Arking4,25; Martina Mu¨ller5-7; Vesela Gateva8; Christian Fuchsberger9; Georg B Ehret4; Marco Orru´ 3; Cristian Pattaro9; Anna Ko¨ttgen10; Siegfried Perz11; Gianluca Usala3; Maja Barbalic12; Man Li10; Benno Pu¨tz13; Angelo Scuteri14; Ronald J Prineas15; Moritz F Sinner7; Christian Gieger5; Samer S Najjar16; W H Linda Kao10; Thomas W Mu¨hleisen17,18; Mariano Dei3; Christine Happle1,2; Stefan Mo¨hlenkamp19; Laura Crisponi3; Raimund Erbel19; Karl-Heinz Jo¨ckel20; Silvia Naitza3; Gerhard Steinbeck7; Fabio Marroni9; Andrew A Hicks9; Edward Lakatta16; Bertram Mu¨ller-Myhsok13; Peter P Pramstaller9,21,22; H-Erich Wichmann5,6; David Schlessinger23; Eric Boerwinkle12; Thomas Meitinger1,2; Manuela Uda3; Josef Coresh10,24; Stefan Ka¨a¨b7; Gonc¸alo R Abecasis8; Aravinda Chakravarti4,24. (2009)
    Common variants at ten loci modulate the QT interval duration in the QTSCD Study
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Arne Pfeufer1,2,25; Serena Sanna3,25; Dan E Arking4,25; Martina Mu¨ller5-7; Vesela Gateva8; Christian Fuchsberger9; Georg B Ehret4; Marco Orru´ 3; Cristian Pattaro9; Anna Ko¨ttgen10; Siegfried Perz11; Gianluca Usala3; Maja Barbalic12; Man Li10; Benno Pu¨tz13; Angelo Scuteri14; Ronald J Prineas15; Moritz F Sinner7; Christian Gieger5; Samer S Najjar16; W H Linda Kao10; Thomas W Mu¨hleisen17,18; Mariano Dei3; Christine Happle1,2; Stefan Mo¨hlenkamp19; Laura Crisponi3; Raimund Erbel19; Karl-Heinz Jo¨ckel20; Silvia Naitza3; Gerhard Steinbeck7; Fabio Marroni9; Andrew A Hicks9; Edward Lakatta16; Bertram Mu¨ller-Myhsok13; Peter P Pramstaller9,21,22; H-Erich Wichmann5,6; David Schlessinger23; Eric Boerwinkle12; Thomas Meitinger1,2; Manuela Uda3; Josef Coresh10,24; Stefan Ka¨a¨b7; Gonc¸alo R Abecasis8; Aravinda Chakravarti4,24. (literal)
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  • 407 (literal)
Pagina fine
  • 414 (literal)
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  • 41 (literal)
Rivista
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  • 4 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Institute of Human Genetics, Helmholtz Center Munich, Germany 2 Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany 3 Istituto di Neurogenetica e Neurofarmacologia, CNR, Monserrato, Cagliari, Italy 4 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA 5 Institute of Epidemiology, Helmholtz Center Munich, Germany 6 Institute of Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany 7 Department of Medicine I, Klinikum Grosshadern, Munich, Germany 8 Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA 9 Institute of Genetic Medicine, EURAC European Academy, Bolzano, Italy 10 Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA 11 Institute of Medical Informatics, Helmholtz Center Munich, Germany 12 Genetics Center, University of Texas Health Science Center, Houston, Texas, USA 13 Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany 14 Unità Operativa Geriatria, Istituto Ricovero e Cura per Anziani, Rome, Italy 15 Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA 16 Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA 17 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany 18 Institute of Human Genetics, University of Bonn, Bonn, Germany 19 Clinic of Cardiology, West German Heart Center, University Hospital of Essen, University Duisburg-Essen, Germany 20 Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Germany 21 Department of Neurology, General Central Hospital, Via Bohler 5, Bolzano, Italy 22 Department of Neurology, University of Lübeck, Lübeck, Germany 23 Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA 24 Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA (literal)
Titolo
  • Common variants at ten loci modulate the QT interval duration in the QTSCD Study (literal)
Abstract
  • The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death (SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We analyze genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P<5 x10-8. Four loci map near the monogenic long-QT syndrome genes KCNQ1, KCNH2, SCN5A and KCNJ2. Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within NDRG4-GINS3-SETD6-CNOT1, respectively, all of which have not previously been implicated in cardiac electrophysiology. These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD. (literal)
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