http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37236
The value of some Corsican sub-populations for genetic association studies. (Articolo in rivista)
- Type
- Label
- The value of some Corsican sub-populations for genetic association studies. (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1186/1471-2350-9-73 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Veronica Latini; Gabriella Sole; Laurent Varesi; Giuseppe Vona and Maria Serafina Ristaldi. Equal contributors (literal)
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- Rivista
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- Note
- ISI Web of Science (WOS) (literal)
- PubMe (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Veronia Latini, Gabriella Sole, Maria Serafina Ristaldi: IRGB-CNR
Lourent Varesi: University of Corte, France
Giuseppe Vona. University of Cagliari (literal)
- Titolo
- The value of some Corsican sub-populations for genetic association studies. (literal)
- Abstract
- Background: Genetic isolates with a history of a small founder population, long-lasting isolation
and population bottlenecks represent exceptional resources in the identification of disease genes.
In these populations the disease allele reveals Linkage Disequilibrium (LD) with markers over
significant genetic intervals, therefore facilitating disease locus identification. In a previous study we
examined the LD extension on the Xq13 region in three Corsican sub-populations from the inner
mountainous region of the island. On the basis of those previous results we have proposed a
multistep procedure to carry out studies aimed at the identification of genes involved in complex
diseases in Corsica. A prerequisite to carry out the proposed multi-step procedure was the
presence of different degrees of LD on the island and a common genetic derivation of the different
Corsican sub-populations. In order to evaluate the existence of these conditions in the present
paper we extended the analysis to the Corsican coastal populations.
Methods: Samples were analyzed using seven dinucleotide microsatellite markers on
chromosome Xq13-21: DXS983, DXS986, DXS8092, DXS8082, DXS1225, DXS8037 and DXS995
spanning approximately 4.0 cM (13.3 Mb). We have also investigated the distribution of the
DXS1225-DXS8082 haplotype which has been recently proposed as a good marker of population
genetic history due to its low recombination rate.
Results: the results obtained indicate a decrease of LD on the island from the central mountainous
toward the coastal sub-populations. In addition the analysis of the DXS1225-DXS8082 haplotype
revealed: 1) the presence of a particular haplotype with high frequency; 2) the derivation from a
common genetic pool of the sub-populations examined in the present study.
Conclusion: These results indicate the Corsican sub-populations useful for the fine mapping of
genes contributing to complex diseases. (literal)
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