Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Articolo in rivista)

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Label
  • Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.76 (literal)
Alternative label
  • Cristen J Willer1;18; Serena Sanna1,2,18; Anne U Jackson1; Angelo Scuteri3,4; Lori L Bonnycastle5; Robert Clarke6; Simon C Heath7; Nicholas J Timpson8; Samer S Najjar3; Heather M Stringham1; James Strait3; William L Duren1; Andrea Maschio2; Fabio Busonero2; Antonella Mulas2; Giuseppe Albai2; Amy J Swift5; Mario A Morken5; Narisu Narisu5; Derrick Bennett6; Sarah Parish6; Haiqing Shen9; Pilar Galan10; Pierre Meneton11; Serge Hercberg11; Diana Zelenika7; Wei-Min Chen1; Yun Li1; Laura J Scott1; Paul A Scheet1; Jouko Sundvall12; Richard M Watanabe13,14; Ramaiah Nagaraja3; Shah Ebrahim15; Debbie A Lawlor8; Yoav Ben-Shlomo8; George Davey-Smith8; Alan R Shuldiner9; Rory Collins6; Richard N Bergman13; Manuela Uda2; Jaakko Tuomilehto16; Antonio Cao2; Francis S Collins5; Edward Lakatta3; G Mark Lathrop7; Michael Boehnke1; David Schlessinger3; Karen L Mohlke17; Gonc¸alo R Abecasis1 (2008)
    Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cristen J Willer1;18; Serena Sanna1,2,18; Anne U Jackson1; Angelo Scuteri3,4; Lori L Bonnycastle5; Robert Clarke6; Simon C Heath7; Nicholas J Timpson8; Samer S Najjar3; Heather M Stringham1; James Strait3; William L Duren1; Andrea Maschio2; Fabio Busonero2; Antonella Mulas2; Giuseppe Albai2; Amy J Swift5; Mario A Morken5; Narisu Narisu5; Derrick Bennett6; Sarah Parish6; Haiqing Shen9; Pilar Galan10; Pierre Meneton11; Serge Hercberg11; Diana Zelenika7; Wei-Min Chen1; Yun Li1; Laura J Scott1; Paul A Scheet1; Jouko Sundvall12; Richard M Watanabe13,14; Ramaiah Nagaraja3; Shah Ebrahim15; Debbie A Lawlor8; Yoav Ben-Shlomo8; George Davey-Smith8; Alan R Shuldiner9; Rory Collins6; Richard N Bergman13; Manuela Uda2; Jaakko Tuomilehto16; Antonio Cao2; Francis S Collins5; Edward Lakatta3; G Mark Lathrop7; Michael Boehnke1; David Schlessinger3; Karen L Mohlke17; Gonc¸alo R Abecasis1 (literal)
Pagina inizio
  • 161 (literal)
Pagina fine
  • 169 (literal)
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  • 40 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA. 2Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy 09042. 3Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA. 4Unita´ Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy. 5Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA. 6Clinical Trial Service Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK. 7Centre National de Ge´notypage, Institut Ge´nomique, Commissariat a` l'E´ nergie Atomique, 2 rue Gaston Cre´mieux, CP 5721, 91057 Evry Cedex, France. 8Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK. 9Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. 10U872 Institut National de la Sante´ et de la Recherche Me´ dicale (INSERM) and De´partement de Sante´ Publique et d'Informatique Me´ dicale, Faculte´ de Me´decine Rene´ Descartes, 15 rue de l'Ecole de Me´decine, 75270 Paris, France. 11U557 INSERM; U1125 Institut National de la Recherche Agronomique (INRA); Cnam; Paris 13 University; Centre de Recherche en Nutrition Humaine (CRNH) IdF, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France. 12Laboratory of Analytical Biochemistry, Department of Health and Functional Capacity, National Public Health Institute, 00300 Helsinki, Finland. 13Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. 14Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. 15Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel St. London WC1E 7HT, UK. 16Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, 00300 Helsinki, Finland and Department of Public Health, University of Helsinki, 00014 Helsinki, Finland. 17Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA. (literal)
Titolo
  • Newly identified loci that influence lipid concentrations and risk of coronary artery disease (literal)
Abstract
  • To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables) and 2,758 individuals from the Diabetes Genetics Initiative, reported in a companion study in this issue. We subsequently examined promising signals in 11,569 additional individuals. Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near TRIB1, MLXIPL and ANGPTL3, with variants primarily associated with triglycerides; and a locus encompassing several genes near NCAN, with variants strongly associated with both triglycerides and LDL cholesterol). Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls. (literal)
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