Common variants in the GDF5-BFZB region are associated with variation in human height. (Articolo in rivista)

Type
Label
  • Common variants in the GDF5-BFZB region are associated with variation in human height. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Serena Sanna,1,2*; Anne U. Jackson,1*; Ramaiah Nagaraja,3; Cristen J. Willer,1; Wei-Min Chen,1,4; Lori L. Bonnycastle,5; Haiqing Shen,6; Nicholas Timpson,7,8; Guillaume Lettre,9; Gianluca Usala,2; Peter S. Chines,5; Heather M. Stringham,1; Mariano Dei,2; Sandra Lai,2; Giuseppe Albai,2; Laura Crisponi,2; Silvia Naitza,2; Kimberly F. Doheny,10; Elizabeth W. Pugh,10; Yoav Ben-Shlomo,7; Shah Ebrahim,11; Debbie A. Lawlor,7,8; Richard N. Bergman,12; Richard M. Watanabe,12,13; Manuela Uda,2; Jaakko Tuomilehto,14; Josef Coresh,15; Joel N. Hirschhorn,9; Alan R. Shuldiner,6,16; David Schlessinger,3; Francis S. Collins,5; George Davey Smith,7,8; Eric Boerwinkle,17; Antonio Cao,2; Michael Boehnke,1; Gonçalo R. Abecasis,1; and Karen L. Mohlke18 (2008)
    Common variants in the GDF5-BFZB region are associated with variation in human height.
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Serena Sanna,1,2*; Anne U. Jackson,1*; Ramaiah Nagaraja,3; Cristen J. Willer,1; Wei-Min Chen,1,4; Lori L. Bonnycastle,5; Haiqing Shen,6; Nicholas Timpson,7,8; Guillaume Lettre,9; Gianluca Usala,2; Peter S. Chines,5; Heather M. Stringham,1; Mariano Dei,2; Sandra Lai,2; Giuseppe Albai,2; Laura Crisponi,2; Silvia Naitza,2; Kimberly F. Doheny,10; Elizabeth W. Pugh,10; Yoav Ben-Shlomo,7; Shah Ebrahim,11; Debbie A. Lawlor,7,8; Richard N. Bergman,12; Richard M. Watanabe,12,13; Manuela Uda,2; Jaakko Tuomilehto,14; Josef Coresh,15; Joel N. Hirschhorn,9; Alan R. Shuldiner,6,16; David Schlessinger,3; Francis S. Collins,5; George Davey Smith,7,8; Eric Boerwinkle,17; Antonio Cao,2; Michael Boehnke,1; Gonçalo R. Abecasis,1; and Karen L. Mohlke18 (literal)
Pagina inizio
  • 198 (literal)
Pagina fine
  • 203 (literal)
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  • 40(2) (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
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  • 1Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA 2Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, 09042, Italy 3Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA 4Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, USA 5Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA 6Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA 7Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK 8Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK 9Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, MA, 02142, USA 10Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA 11London School of Hygiene and Tropical Medicine, University of London, London WC1E 7HT, UK 12Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA 13Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA 14Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, 00300 Helsinki, Finland and Department of Public Health, University of Helsinki, 00014 Helsinki, Finland 15Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA 16Geriatric Research and Education Center, Veterans Administration Medical Center, Baltimore, MD 21201, USA 17Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77225, USA 18Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA (literal)
Titolo
  • Common variants in the GDF5-BFZB region are associated with variation in human height. (literal)
Abstract
  • Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population. Here we report genome-wide association analyses, using genotyped and imputed markers, of 6,669 individuals from Finland and Sardinia, and follow-up analyses in an additional 28,801 individuals. We show that common variants in the osteoarthritis-associated locus GDF5-UQCC contribute to variation in height with an estimated additive effect of 0.44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development. (literal)
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