http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37224
The GLUT9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. (Articolo in rivista)
- Type
- Label
- The GLUT9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1371/journal.pgen.0030194 (literal)
- Alternative label
Siguang Li, 1; Serena Sanna, 2; Andrea Maschio, 2; Fabio Busonero, 2; Gianluca Usala, 2; Antonella Mulas,2; Sandra Lai,2; Mariano Dei,2; Marco Orrù,2; Giuseppe Albai,2; Stefania Bandinelli,3; David Schlessinger,1; Edward Lakatta,4; Angelo Scuteri,4,5; Samer S Najjar,4; Jack Guralnik,6; Silvia Naitza,2; Laura Crisponi,2; Antonio Cao,2; Gonçalo Abecasis,7; Luigi Ferrucci,8; Manuela Uda,2; Wei-Min Chen,7; Ramaiah Nagaraja1 (2007)
The GLUT9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts.
in PLOS genetics
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Siguang Li, 1; Serena Sanna, 2; Andrea Maschio, 2; Fabio Busonero, 2; Gianluca Usala, 2; Antonella Mulas,2; Sandra Lai,2; Mariano Dei,2; Marco Orrù,2; Giuseppe Albai,2; Stefania Bandinelli,3; David Schlessinger,1; Edward Lakatta,4; Angelo Scuteri,4,5; Samer S Najjar,4; Jack Guralnik,6; Silvia Naitza,2; Laura Crisponi,2; Antonio Cao,2; Gonçalo Abecasis,7; Luigi Ferrucci,8; Manuela Uda,2; Wei-Min Chen,7; Ramaiah Nagaraja1 (literal)
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- ISI Web of Science (WOS) (literal)
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- 1 Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America
2 Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy
3 Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy
4 Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, United States of America
5 Unità Operativa Geriatria, Istituto Nazionale Ricovero e Cura Anziani, Rome, Italy
6 Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, United States of America
7 Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
8 Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America (literal)
- Titolo
- The GLUT9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. (literal)
- Abstract
- High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 × 10-16), along with eight others (p = 7.75 × 10-16 to 6.05 × 10-11). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. (literal)
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