http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37194
Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system. (Articolo in rivista)
- Type
- Label
- Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.chemphyslip.2005.02.010 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Caboi F; Lazzari P; Pani L; Monduzzi M. (literal)
- Pagina inizio
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento Scienze Chimiche, CSGI Universit`a di Cagliari, S.S. 554 Bivio Sestu, 09042 Monserrato, CA, Italy
Neuroscienze PharmaNess S.c.a r.l., Via Palabanda 9, 09123 Cagliari, Italy
C.N.R. Institute of Neurogenetic and Neuropharmacology, Via Boccaccio 8, 09047 Selargius, CA, Italy (literal)
- Titolo
- Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system. (literal)
- Abstract
- Warm microemulsions based on lipids characterized by a melting point over 50 degrees C have been successfully used as starting matrix in a quenching process to obtain solid lipid nanoparticles (SLN). In this work, we have investigated the effect of 1-butanol (B) on the phase behavior of the lecithin (LCT)/water (W)/tripalmitin (TP) system at 70 degrees C. The study has been carried out at LCT/B=1 (weight ratio). Emulsion and liquid crystalline phase regions have been observed in the ternary phase diagram, while the presence of 1-butanol in the LCT/W/B/TP system allows the formation of a wide area of liquid isotropic phase from the whole (LCT+B)/TP binary axis up to 37 wt% of water. The microstructure of this isotropic phase has been investigated by means of 1H NMR PGSE technique. The self-diffusion coefficients of the different components along oil and water dilution lines indicate a microstructural organization characterized by a highly connected water in oil domains. (literal)
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