http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37192
Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors. (Articolo in rivista)
- Type
- Label
- Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Alternative label
Tambaro S, Mongeau R, Dessi C, Pani L, Ruiu S. (2005)
Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors.
in European journal of pharmacology
(literal)
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- Tambaro S, Mongeau R, Dessi C, Pani L, Ruiu S. (literal)
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- ISI Web of Science (WOS) (literal)
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- Neuroscienze-PharmaNess S.c.ar.l (literal)
- Titolo
- Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors. (literal)
- Abstract
- The effect of R-(+)-[2,3-dihydro-5-methyl-3-[(morpholiny)methyl]pyrolol[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (WIN 55,212-2; a cannabinoid receptor agonist) was investigated on contractions of the bisected (epididymal and prostatic portions) rat vas deferens to assess the role of cannabinoid receptors in sympathetic ATP neurotransmission. WIN 55,212-2 inhibited the electrically induced contractions in both portions of the rat vas deferens. In the presence of the alpha1-adrenoreceptor antagonist prazosin, electrical stimulation produces a contraction mediated exclusively by ATP. In this condition, WIN 55,212-2 in the prostatic portion elicited a concentration-dependent inhibition that was antagonized by N-piperidinyl-[8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide] (NESS 0327), a selective cannabinoid CB1 receptor antagonist. NESS 0327 caused a parallel dextral displacement of the WIN 55,212-2 concentration-response curve. It is suggested that activation of pre-junctional cannabinoid receptors on sympathetic nerves of the vas deferens modulates ATP neurotransmission. (literal)
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