http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37180
Haloperidol, but not clozapine, produces dramatic catalepsy in Delta9-THC-treated rats: possible clinical implications (Articolo in rivista)
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- Haloperidol, but not clozapine, produces dramatic catalepsy in Delta9-THC-treated rats: possible clinical implications (Articolo in rivista) (literal)
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- 2003-01-01T00:00:00+01:00 (literal)
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Marchese G, Casti P, Ruiu S, Saba P, Sanna A, Casu G, Pani L. (2003)
Haloperidol, but not clozapine, produces dramatic catalepsy in Delta9-THC-treated rats: possible clinical implications
in British journal of pharmacology
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- Marchese G, Casti P, Ruiu S, Saba P, Sanna A, Casu G, Pani L. (literal)
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- Titolo
- Haloperidol, but not clozapine, produces dramatic catalepsy in Delta9-THC-treated rats: possible clinical implications (literal)
- Abstract
- The effect on rat catalepsy induced by Delta9-tetrahydrocannabinol (Delta9-THC) in association with haloperidol (HP) or clozapine (CLOZ) administration was investigated. Delta9-THC dose-dependently increased HP (0.05-1 mg kg-1, s.c.)-induced rat catalepsy, while no catalepsy was observed after CLOZ (1-20 mg kg-1, s.c.) or Delta9-THC+CLOZ administration. The CB1 antagonist SR141716A (0.5-5 mg kg-1, i.p.) reversed the increase mediated by Delta9-THC on HP-induced catalepsy. The D2 agonist quinpirole completely reversed the catalepsy induced by both HP and HP+Delta9-THC; however, higher doses of quinpirole were needed in the presence of Delta9-THC. The M1 antagonist scopolamine and alpha2 antagonist yohimbine were able to reduce the catalepsy induced by HP and HP+Delta9-THC in a similar manner. CLOZ and the 5-HT2A/2C antagonists ritanserin, RS102221 and SB242084 were more effective in antagonizing HP than HP+Delta9-THC-induced catalepsy.7 HP and CLOZ failed to inhibit in vitro [3H]CP-55,940 binding, while Delta9-THC and SR141716A did not show an appreciable affinity for the D2 receptor. It was suggested that the different effects on rat catalepsy induced by Delta9-THC following HP or CLOZ administration may depend on the receptor-binding profiles of the two antipsychotics. The preferential use of CLOZ rather than HP in the treatment of psychotic symptoms in cannabis abusers was discussed. (literal)
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