Effects of aluminium sulphate in the mouse liver: Similarities to the aging process (Articolo in rivista)

Type
Label
  • Effects of aluminium sulphate in the mouse liver: Similarities to the aging process (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Stacchiotti, A; Lavazza, A; Ferroni, M; Sberveglieri, G; Bianchi, R; Rezzani, R; Rodella, LF (2008)
    Effects of aluminium sulphate in the mouse liver: Similarities to the aging process
    in Experimental gerontology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Stacchiotti, A; Lavazza, A; Ferroni, M; Sberveglieri, G; Bianchi, R; Rezzani, R; Rodella, LF (literal)
Pagina inizio
  • 330 (literal)
Pagina fine
  • 338 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 43 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • \"[Stacchiotti, Alessandra; Rezzani, Rita; Rodella, Luigi Fabrizio] Univ Brescia, Dept Biomed Sci & Biotechnol, Div Human Anat, I-25123 Brescia, Italy; [Lavazza, Antonio] Ist Zooprofilatt Sperimentale Lombardia & Emilia, I-25124 Brescia, Italy; [Ferroni, Matteo; Sberveglieri, Giorgio] Univ Brescia, INFM, CNR, I-25123 Brescia, Italy; [Ferroni, Matteo] Univ Brescia, Dept Chem & Phys, I-25123 Brescia, Italy; [Bianchi, Rossella] Univ Milan, Dept Human Morphol, I-20133 Milan, Italy (literal)
Titolo
  • Effects of aluminium sulphate in the mouse liver: Similarities to the aging process (literal)
Abstract
  • Aluminium (Al) is a ubiquitous metal that is potentially toxic to the brain. Its effects on other fundamental organs are not completely understood. This morphological in vivo study sought to compare sublethal hepatotoxic changes and Al deposition in adult mice that orally ingested Al sulphate daily for 10 months, in age matched control mice that drank tap water and in senescent mice (24 months old). Livers were examined for collagen deposition using Sirius red and Masson, for iron accumulation using Perls' stain. Light, electron microscopy and morphometry were used to assess fibrosis and vascular changes. Scanning transmission electron microscopy and EDX microanalysis were used to detect in situ elemental Al. Iron deposition, transferrin receptor expression were significantly altered following Al exposure and in the aged liver but were unaffected in age matched control mice. In Al treated mice as in senescent mice, endothelial thickness was increased and porosity was decreased like perisinusoidal actin. Furthermore, Al stimulated the deposition of collagen and laminin, mainly in acinar zones 1 and 3. Pseudocapillarization and periportal laminin in senescent mice were similar to Al treated adult liver. In conclusion, prolonged Al sulphate intake accelerates features of senescence in the adult mice liver. (C) 2008 Elsevier Inc. All rights reserved. (literal)
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