http://www.cnr.it/ontology/cnr/individuo/prodotto/ID35653

Au nanoparticles prepared by physical method on Si and sapphire substrates for biosensor applications (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Au nanoparticles prepared by physical method on Si and sapphire substrates for biosensor applications (Articolo in rivista) (literal)

Anno

2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1021/jp053194j (literal)

Alternative label

Spadavecchia J., Prete P., Lovergine N., Tapfer L., Rella R. (2005)
Au nanoparticles prepared by physical method on Si and sapphire substrates for biosensor applications
in The journal of physical chemistry. B; American Chemical Society, Washington (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Spadavecchia J., Prete P., Lovergine N., Tapfer L., Rella R. (literal)

Pagina inizio

17347 (literal)

Pagina fine

17349 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

109 (literal)

Rivista

?The ?journal of physical chemistry. B (Rivista)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

CNR, IMM, Sez Lecce, I-73100 Lecce, Italy; Univ Lecce, Dipartimento Ingn Innovaz, I-73100 Lecce, Italy; UTS, MAT, ENEA, Ctr Ric Brindisi, I-72100 Brindisi, Italy (literal)

Titolo

Au nanoparticles prepared by physical method on Si and sapphire substrates for biosensor applications (literal)

Abstract

Gold nanoparticles heavily functionalized with oligonucleotides have been used in a variety of DNA detection methods. The optical properties of three-dimensional aggregates of Au nanoparticles in solution or deposited onto suitable surfaces have been analyzed to detect hybridization processes of specific DNA sequences as possible alternatives to fluorescent labeling methods. This paper reports on the preparation of gold nanoparticles directly deposited onto the surface of silicon (Si) and sapphire (Al2O3) substrates by a physical methodology, consisting in the thermal evaporation of a thin Au film and its successive annealing. The method guarantees the preparation of monodispersed single-crystal An nanoparticles with a strong surface plasmon resonance (SPR) peak centered at about 540 nm. We show that the changes of SPR excitation before and after DNA functionalization and subsequent hybridization of Au nanoparticles immobilized onto Si and Al2O3 substrates can be exploited to fabricate specific biosensors devices in solid phase. (literal)
Gold nanoparticles heavily functionalized with oligonucleotides have been used in a variety of DNA detection methods. The optical properties of three-dimensional aggregates of Au nanoparticles in solution or deposited onto suitable surfaces have been analyzed to detect hybridization processes of specific DNA sequences as possible alternatives to fluorescent labeling methods. This paper reports on the preparation of gold nanoparticles directly deposited onto the surface of silicon (Si) and sapphire (Al2O3) substrates by a physical methodology, consisting in the thermal evaporation of a thin Au film and its successive annealing. The method guarantees the preparation of monodispersed single-crystal Au nanoparticles with a strong surface plasmon resonance (SPR) peak centered at about 540 nm. We show that the changes of SPR excitation before and after DNA functionalization and subsequent hybridization of Au nanoparticles immobilized onto Si and Al2O3 substrates can be exploited to fabricate specific biosensors devices in solid phase (literal)

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