http://www.cnr.it/ontology/cnr/individuo/prodotto/ID34404
Increasing Cell Adhesion on Plasma Deposited Fluorocarbon Coatings by Changing the Surface Topography (Articolo in rivista)
- Type
- Label
- Increasing Cell Adhesion on Plasma Deposited Fluorocarbon Coatings by Changing the Surface Topography (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jbm.b.31160 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- R. Gristina; E. D'Aloia; G.S. Senesi; A. Milella; M. Nardulli; E. Sardella; P. Favia; R. d'Agostino (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Inorganic Methodologies and Plasmas (IMIP), CNR; Department of Chemistry, University of Bari (literal)
- Titolo
- Increasing Cell Adhesion on Plasma Deposited Fluorocarbon Coatings by Changing the Surface Topography (literal)
- Abstract
- In designing new biomaterials, it is of outstanding importance to consider how cells
respond to specific chemical and topographical features on the material surface. The behavior
of most cell types in vivo is strictly related to specific chemical and topographical cues that
characterize the extra cellular environment. In particular, during their lives cells react to
topographical patterns such as those of the extracellular matrix (ECM), of micro and/or
nanometric dimensions. The production of micrometric and/or nanometric features on
artificial materials usually involves expensive and time-consuming methods of manufacturing,
such as electron beam and colloidal lithography. In this article, different ''Teflon-like''
structured surfaces were deposited from tetrafluoroethylene (C2F4)-fed plasmas, for the study
of cell adhesion and growth. The reaction of different cell lines to different topographical
features was evaluated and compared with cell behavior on flat samples with the same
chemical composition. Cell adhesion was calculated from area covered by cells at different
time of culture. Beside this, cell proliferation was determined with the MTT test. Cell
morphology and filopodia interaction with the nanofeatures were also estimated by optical and
scanning electron microscopy. A dramatic difference both in adhesion and growth was found
between cells seeded on flat and rough surfaces with the density and spreading of adhered cells
varying as a function of the roughness of coatings. (literal)
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