http://www.cnr.it/ontology/cnr/individuo/prodotto/ID33614
kinetics of demetallation of a zinc-salophen complex into liposomes (Articolo in rivista)
- Type
- Label
- kinetics of demetallation of a zinc-salophen complex into liposomes (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bbamem.2011.10.014 (literal)
- Alternative label
C. Gasbarri, G. Angelini, A. Fontana, P. De Maria, G. Siani, I. Giannicchi, A. Dalla Cort (2012)
kinetics of demetallation of a zinc-salophen complex into liposomes
in Biochimica et biophysica acta (Print); elsevier B.V., Amsterdam (Paesi Bassi)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- C. Gasbarri, G. Angelini, A. Fontana, P. De Maria, G. Siani, I. Giannicchi, A. Dalla Cort (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- Scopus (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, via dei Vestini, 66013 Chieti, Italy
Dipartimento di Chimica and IMC-CNR Università \"La Sapienza\", piazzale A. Moro, 00185 Roma, Italy (literal)
- Titolo
- kinetics of demetallation of a zinc-salophen complex into liposomes (literal)
- Abstract
- A Zn-salophen complex has been incorporated into POPC large unilamellar liposomes (LUV) obtained in
phosphate buffer at pH 7.4. Fluorescence optical microscopy and anisotropy measurements show that the
complex is located at the liposomal surface, close to the polar headgroups. The interaction of the POPC phosphate
group with Zn2+ slowly leads to demetallation of the complex. The process follows first order kinetics
and rate constants have been measured fluorimetrically in pure water and in buffered aqueous solution.
The coordination of the phosphate group of monomeric POPC with salophen zinc also occurs in chloroform as
detected by ESI-MS measurements.
The effect of the Zn-salophen complex on the stability of POPC LUV has been evaluated at 25 °C by measuring
the rate of release of entrapped 5(6)-carboxyfluorescein (CF) in the presence and in the absence of Triton
X-100 as the perturbing agent. It turns out that the inclusion of the complex significantly increases the stability
of POPC LUV. (literal)
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