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Infuence of lipid composition on the thermotropic behavior and size distribution of mixed cationic liposomes (Articolo in rivista)

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Infuence of lipid composition on the thermotropic behavior and size distribution of mixed cationic liposomes (Articolo in rivista) (literal)

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Y. Barenholz, C. Bombelli, M. G. Bonicelli, P. di Profio, L. Giansanti, G. Mancini, F. Pascale (2011)
Infuence of lipid composition on the thermotropic behavior and size distribution of mixed cationic liposomes
in Journal of colloid and interface science (Print); Elsevier Inc., San Diego (Stati Uniti d'America)
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Y. Barenholz, C. Bombelli, M. G. Bonicelli, P. di Profio, L. Giansanti, G. Mancini, F. Pascale (literal)

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Laboratory of Membrane and Liposome Research, Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel CNR, Istituto di metodologie chimiche and Dipartimento di Chimica Università degli studi di Roma ''La Sapienza'', P.le A.Moro 5, 00185 Rome, Italy Dipartimento di Ingegneria Chimica, dei Materiali, delle Materie Prime e dell'Ambiente Università degli studi di Roma ''La Sapienza'', P.le A.Moro 5, 00185 Rome, Italy Centro di Eccellenza Materiali Innovativi Nanostrutturati (CEMIN), Dipartimento di Chimica, Università di Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy Dipartimento di Chimica Università degli studi di Roma ''La Sapienza'', P.le A.Moro 5, 00185 Rome, Italy (literal)

Titolo

Infuence of lipid composition on the thermotropic behavior and size distribution of mixed cationic liposomes (literal)

Abstract

Cationic liposomes are studied mainly as nonviral nucleic acid delivery systems and to a lesser extent as carriers/adjuvants of vaccines and as low-molecular-weight drug carriers. It is well established that the performance and the biological activity of liposomes in general are strongly related to their physicochemical properties. We investigated the thermotropic behavior and the size distribution of mixed cationic liposomes formulated with different percentages of 1,2 dimyristoyl-sn-glycero-3-phosphatidylcholine and one of four cationic amphiphiles characterized by a pyrrolidinium headgroup with the aim of achieving a better understanding of how the molecular structure of the cationic amphiphile and its mole percentage affect the physicochemical properties of the liposomes. Multilamellar vesicles and large unilamellar vesicles were studied by differential scanning calorimetry and turbidity, respectively, to characterize the thermotropic behavior and lipid phase, whereas dynamic light scattering was used to determine size distribution. This study shows that subtle modifications in the cationic amphiphile's molecular structure and in liposome composition may have dramatic effects on the organization of the liposome bilayer and hence on the morphological and physicochemical features of the liposomes, thus being highly relevant to the biological features investigated previously. (literal)

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