Efficiency of Liposomes in the Delivery of a Photosensitizer Controlled by the Stereochemistry of a Gemini Surfactant Component (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Efficiency of Liposomes in the Delivery of a Photosensitizer Controlled by the Stereochemistry of a Gemini Surfactant Component (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/mp900173v (literal)

Alternative label

• Bombelli C.; Stringaro A.; Borocci S.; Bozzuto G.; Colone M.; Giansanti L.; Sgambato R.; Tocaceli L.; Mancini G.; Molinari A. (2010)
  Efficiency of Liposomes in the Delivery of a Photosensitizer Controlled by the Stereochemistry of a Gemini Surfactant Component
  in Molecular pharmaceutics (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bombelli C.; Stringaro A.; Borocci S.; Bozzuto G.; Colone M.; Giansanti L.; Sgambato R.; Tocaceli L.; Mancini G.; Molinari A. (literal)

Pagina inizio

• 130 (literal)

Pagina fine

• 137 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Molecular pharmaceutics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• Scopus (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Istituto di Metodologie Chimiche Dipartimento di Chimica, Univesità degli Studi di Roma \"La Sapienza\" Università della Tuscia Istituto Superiore di Sanità (literal)

Titolo

• Efficiency of Liposomes in the Delivery of a Photosensitizer Controlled by the Stereochemistry of a Gemini Surfactant Component (literal)

Abstract

• Liposomes formulated with dimyristoyl-sn-glycero-phosphatidylcholine, DMPC, and either one of the cationic gemini surfactants (S,S)-2,3-dimethoxy-1,4-bis(N-hexadecyl-N,N-dimethylammonio)butane bromide, 1a, and (S,R)-2,3-dimethoxy-1,4-bis(N-hexadecyl-N,N-dimethylammonio)butane bromide, 1b, were investigated as vehicles of the photosensitizer m-tetrahydroxyphenylchlorin, m-THPC, to cell models of malignant glioma. The delivery efficiency of DMPC/1a and DMPC/1b liposome formulations were evaluated on the murine glioblastoma cell line C6 and on the human glioblastoma cell line LN229 by flow cytometry and laser scanning confocal microscopy. The stereochemistry of the spacer of the gemini was found to strongly influence the delivery efficiency of m-THPC to cells, the mode of interaction with the cell membrane, and the intracellular distribution of m-THPC. The physicochemical features of liposomes were investigated with the aim of explaining the parameters that control their biological features. Differences that could account for the different biological activity of the formulations concern the values of surface potential and the environment of m-THPC at the water/liposome interface. (literal)

Prodotto di

• Metodologie, nanoparticelle e nutraceutici in nanomedicina (PM.P05.002.001) (Modulo)
• Istituto di metodologie chimiche (IMC) (Istituto)

Autore CNR

• CECILIA BOMBELLI (Persona)
• GIOVANNA MANCINI (Unità di personale interno)
• Luisa Giansanti (Unità di personale esterno)

Incoming links:

Prodotto

• Istituto di metodologie chimiche (IMC) (Istituto)
• Metodologie, nanoparticelle e nutraceutici in nanomedicina (PM.P05.002.001) (Modulo)

Autore CNR di

• GIOVANNA MANCINI (Unità di personale interno)
• Luisa Giansanti (Unità di personale esterno)
• CECILIA BOMBELLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular pharmaceutics (Rivista)