http://www.cnr.it/ontology/cnr/individuo/prodotto/ID33457

Ion-pair Binding: Is Binding Both Binding Better? (Articolo in rivista)

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Ion-pair Binding: Is Binding Both Binding Better? (Articolo in rivista) (literal)

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Alternative label

Stefano Roelens; Alberto Vacca; Oscar Francesconi; Chiara Venturi (2009)
Ion-pair Binding: Is Binding Both Binding Better?
in Chemistry - A European Journal
(literal)

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Istituto di Metodologie Chimiche (IMC), Consiglio Nazionale delle Ricerche (CNR); Dipartimento di Chimica, Università di Firenze; Centro di Risonanze Magnetiche (CERM), Università di Firenze (literal)

Titolo

Abstract

It is often tempting to explain chemical phenomena on the basis of intuitive principles, but this practice can frequently lead to biased analysis of data and incorrect conclusions. One such intuitive principle is brought into play in the binding of salts by synthetic receptors. Following the heuristic concept that \"binding both is binding better\", it is widely believed that ditopic receptors capable of binding both ionic partners of a salt are more effective than monotopic receptors because of a cooperative effect. Using a newly designed ditopic receptor and a generalized binding descriptor, we show here that, when the problem is correctly formulated and the appropriate algorithm is derived, the cooperativity principle is neither general nor predictable, and that competition between ion binding and ion pairing may even lead to inhibition rather than enhancement of the binding of an ion to a ditopic receptor. (literal)

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